| Title: | Association of triglyceride-glucose index with risk of stroke and all-cause mortality in individuals with diabetes |
| Journal: | Future Cardiology |
| Published: | 18 Aug 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40985184/ |
| DOI: | https://doi.org/10.1080/14796678.2025.2564029 |
Publication 19728
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Abstract
BACKGROUND: The triglyceride - glucose (TyG) index is a surrogate of insulin resistance and may predict vascular risk. We evaluated whether baseline TyG is associated with incident stroke and all-cause mortality in adults with diabetes.</p>
METHODS: We analyzed 10,000 UK Biobank participants with diabetes and no baseline cardiovascular disease. TyG was calculated from fasting triglycerides and glucose and categorized into quartiles. Outcomes (stroke; all-cause mortality) were ascertained via hospital and death registries. Cox models estimated hazard ratios (HRs) adjusting for demographic, lifestyle, and clinical covariates.</p>
RESULTS: Over a median 12.8 years, 620 strokes and 688 deaths occurred. Compared with Q1, Q4 had higher risks of stroke (HR 1.45, 95% CI 1.18-1.80) and mortality (HR 1.42, 95% CI 1.17-1.73). Each 1-SD higher TyG was associated with ~ 19% higher stroke risk (HR 1.19, 95% CI 1.07-1.32) and ~ 16% higher mortality risk (HR 1.16, 95% CI 1.05-1.29). Associations were consistent across age, sex, and BMI subgroups and robust in sensitivity analyses, including extended adjustment.</p>
CONCLUSIONS: Higher TyG is independently associated with increased risks of stroke and all-cause mortality among individuals with diabetes. As an inexpensive measure derived from routine tests, TyG may aid risk stratification and inform targeted prevention in this high-risk population.</p>
16 Keywords
- Adult
- Aged
- Biomarkers
- Blood Glucose
- Cause of Death
- Diabetes Mellitus
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Risk Assessment
- Risk Factors
- Stroke
- Triglycerides
- United Kingdom
3 Authors
- Zhengjun Wu
- Hong Liu
- Mingfang He
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