| Title: | Clinical Utility of Plasma GFAP and NEFL as Biomarkers for Dementia in the Community |
| Journal: | Journal of Neurochemistry |
| Published: | 28 Aug 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40873267/ |
| DOI: | https://doi.org/10.1111/jnc.70210 |
Publication 19638
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Abstract
Plasma glial fibrillary acidic protein (GFAP) and neurofilament light chain (NEFL) are promising dementia biomarkers, yet underexplored in community settings. We studied 36 153 UK Biobank participants (aged 39-70 years, median follow-up: 10.53 years) to assess the biomarkers' predictive performance using receiver operating characteristic (ROC) analysis and their influencing factors using linear regression. GFAP and NEFL demonstrated specific, strong predictive value for Alzheimer's disease (AD) and vascular dementia (VaD) (AUC = 0.76-0.83). Mechanistically, both biomarkers correlated with larger ventricular volumes and slower reaction times. Their levels were influenced by demographics and environmental factors such as smoking, comorbid chronic kidney disease, and diabetes. Genetic analysis showed GFAP levels were influenced by genetic polymorphisms, especially rs429358 mapped to APOE. Incorporating these factors significantly improved predictive accuracy for dementia (AUC = 0.86-0.89). These results could support the establishment of clinical reference ranges, enhancing screening and prediction utility of GFAP and NEFL in the community.</p>
11 Keywords
- Adult
- Aged
- Alzheimer Disease
- Biomarkers
- Dementia
- Female
- Glial Fibrillary Acidic Protein
- Humans
- Male
- Middle Aged
- Neurofilament Proteins
7 Authors
- Hai-Yun Li
- Yue-Ting Deng
- Yu Guo
- Yi Zhang
- Jian-Feng Feng
- Wei Cheng
- Jin-Tai Yu
1 Application
| Application ID | Title |
|---|---|
| 19542 | Identifying multi-level biomarkers and disease mechanisms for major mental disorders |
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