| Title: | Association of Plasma Omega-3 Fatty Acids With POAG |
| Journal: | Investigative Ophthalmology & Visual Science |
| Published: | 29 Aug 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40891782/ |
| DOI: | https://doi.org/10.1167/iovs.66.12.3 |
| URL: | https://iovs.arvojournals.org/arvo/content_public/journal/iovs/938729/i1552-5783-66-12-3_1756461646.92047.pdf |
Publication 19625
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Abstract
Purpose: To investigate the association between plasma levels of omega-3 fatty acids and the risk of POAG.</p>
Methods: We conducted prospective cohort analyses among 254,157 participants of European descent in the UK Biobank cohort. Mendelian randomization analyses were further performed to assess the causal relationship between omega-3 fatty acids and POAG using publicly available genome-wide association study summary statistics.</p>
Results: Over 13.84 years of follow-up, 1,166 patients (0.46%) developed POAG. After adjustment for covariates including POAG polygenetic risk scores, a 1-unit (mmol/L) increment in plasma levels of omega-3 polyunsaturated fatty acids was significantly associated with a decreased risk of incident POAG (hazard ratio, 0.61; 95% confidence interval, 0.43-0.88; P = 0.008). The association of plasma docosahexaenoic acid (DHA) levels with the risk of POAG was borderline significant (hazard ratio, 0.42; 95% confidence interval, 0.17-1.01; P = 0.05). Moreover, the associations were more prominent among individuals with high glaucoma genetic risks, although no significant interaction was detected between omega-3/DHA levels and glaucoma polygenic risk scores (all P > 0.05). For Mendelian randomization analyses, the results of random-effect inverse-variance weighted models and two other sensitivity analyses indicated that genetically predicted plasma levels of omega-3 and DHA were significantly inversely associated with the risk of POAG (all P < 0.05).</p>
Conclusions: Our findings suggested a protective effect of omega-3 fatty acids on POAG, underscoring their potential value in POAG prevention strategies.</p>
16 Keywords
- Aged
- Docosahexaenoic Acids
- Fatty Acids, Omega-3
- Female
- Follow-Up Studies
- Genome-Wide Association Study
- Glaucoma, Open-Angle
- Humans
- Incidence
- Male
- Mendelian Randomization Analysis
- Middle Aged
- Polymorphism, Single Nucleotide
- Prospective Studies
- Risk Factors
- United Kingdom
8 Authors
- Jia-Yan Kai
- Xing-Xuan Dong
- Dan-Lin Li
- Dan-Ning Hu
- Carla Lanca
- Andrzej Grzybowski
- Chaofu Ke
- Chen-Wei Pan
1 Application
| Application ID | Title |
|---|---|
| 60651 | Patterns, outcomes and predictors of non-communicable diseases and multimorbidity |
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