| Title: | Association of physical activity with incident chronic kidney disease in patients with cardiovascular metabolic disease: A UK Biobank observational study |
| Journal: | Journal of Science and Medicine in Sport |
| Published: | 2 Sep 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40987686/ |
| DOI: | https://doi.org/10.1016/j.jsams.2025.08.020 |
| URL: | https://www.jsams.org/article/S1440-2440(25)00414-1/pdf |
Publication 19590
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Abstract
OBJECTIVES: This study examined the association between physical activity and chronic kidney disease incidence among participants with cardiovascular metabolic disease.</p>
DESIGN: A prospective cohort study of 224,269 cardiovascular metabolic disease participants from the UK Biobank, with chronic kidney disease incidence as the primary outcome.</p>
METHODS: The association between physical activity and chronic kidney disease was evaluated using Cox models, assessing volume, intensity, duration, frequency, type, and walking speed. An isotemporal substitution model estimated the effect of replacing light physical activity with moderate or vigorous physical activity. Latent class analysis identified optimal physical activity patterns.</p>
RESULTS: Over a median follow-up of 12.9 years, 10,142 participants developed chronic kidney disease. Compared with light physical activity, moderate and vigorous physical activity reduced incident chronic kidney disease by 13 % and 21 %, respectively. Substituting light with vigorous physical activity was linked to an 11 % risk reduction. Moderate physical activity (3-5 or 6-7 days/week) resulted in risk reductions of 9 % and 7 %, respectively, while vigorous physical activity (3-5 days/week) led to a 20 % reduction. Aerobic exercise reduced chronic kidney disease risk by 20 % versus light Do It Yourself. Compared to slow-paced walkers, those with steady average (hazard ratio, 0.70; 95 % confidence interval: 0.66-0.75) or brisk pace (hazard ratio, 0.61; 95 % confidence interval: 0.56-0.66) had significantly lower risks. The optimal activity for cardiovascular metabolic disease participants is vigorous physical activity 15-60 minutes/day or light physical activity 30-60 minutes/day, 3-5 days/week.</p>
CONCLUSIONS: Physical activity is associated with a lower chronic kidney disease risk in cardiovascular metabolic disease participants.</p>
14 Keywords
- Aged
- Cardiovascular Diseases
- Exercise
- Female
- Humans
- Incidence
- Male
- Metabolic Diseases
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Renal Insufficiency, Chronic
- UK Biobank
- United Kingdom
7 Authors
- Hongyan Liu
- Zhongli Wang
- Saijun Zhou
- Yao Lin
- Guangyang Ma
- Rui Zhang
- Pei Yu
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