| Title: | A phenome-wide association and Mendelian randomization study for suicide attempt within UK Biobank |
| Journal: | Molecular Psychiatry |
| Published: | 2 Sep 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40897861/ |
| DOI: | https://doi.org/10.1038/s41380-025-03214-7 |
Publication 19587
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Abstract
Uncertainties persist in the neurological and behavioral risk factors for suicide attempt (SA) due to a lack of data covering multiple phenotypes. Here, the polygenic risk scores (PRSs) for SA samples within the UK Biobank (N = 40,369) were estimated using non-overlapping Psychiatric Genomics Consortium datasets as a reference. A total of 70 PRS-associated phenotypes encompassing discovered and never-reported phenotypes were identified, thereby facilitating applications in SA identification (area under the curve of 84%). Different with the existing observational studies, the causal effects between brain and SA were explored. Mendelian randomization supported a potential causal effect of right hippocampal gray matter volume on SA, whereas SA had a reverse causal effect on the VI cerebellum. After controlling for the effects of psychiatric disorders, the right hippocampus still had an independent causal effect on SA. These findings provide multi-perspective evidence for early understanding and identification of SA and shed new lights for causal inference between brain and SA.</p>
10 Authors
- Meiyan Huang
- Xiaoling Zhang
- Xiumei Chen
- Xinyue Zhang
- Bingxin Zhao
- Chao Huang
- Ting Tian
- Chuang Li
- Qianjin Feng
- Wenliang Pan
1 Application
| Application ID | Title |
|---|---|
| 68640 | Exploring the possible risk factors of COVID-19 by combined genetic, functional genomic, clinical, and imaging data |
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