| Title: | Association between weekend recovery sleep and risk of incident dementia: a prospective cohort study in the UK Biobank |
| Journal: | Journal of Neurology |
| Published: | 5 Sep 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40911069/ |
| DOI: | https://doi.org/10.1007/s00415-025-13363-y |
Publication 19558
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Abstract
BackgroundSleep deprivation has been linked to higher dementia risk, but the role of weekend recovery sleep (WRS) in mitigating this risk remains unclear. This study aims to evaluate the association between WRS and dementia risk.MethodsThis prospective cohort study followed 88,592 dementia-free adults aged 40-79 years from the UK Biobank, using wrist accelerometers to measure average weekday and weekend sleep durations. Incident dementia (all-cause dementia, Alzheimer's disease [AD], vascular dementia [VaD], and nonspecific dementia) was determined using medical records. Associations were estimated using Cox proportional hazards models and restricted cubic splines (RCS).ResultsAmong 88,592 participants (mean [SD] age, 61.9 [7.9] years), 735 (0.83%) developed dementia, including 308 (0.35%) cases of AD, 137 (0.15%) cases of VaD, and 319 (0.36%) cases of nonspecific dementia. RCS analyses revealed optimal weekday sleep durations associated with the lowest dementia risk: 8.38 h (HR, 0.73; 95% CI 0.64-0.84) for all-cause dementia, 8.33 h (HR, 0.72; 95% CI 0.58-0.89) for AD, and 9.07 h (HR, 0.59; 95% CI 0.40-0.88) for VaD. In the suboptimal sleep group (weekday sleep less than optimal duration), longer WRS was associated with reduced risks of all-cause dementia (HR, 0.801; 95% CI 0.717-0.893) and VaD (HR, 0.747; 95% CI 0.612-0.91). However, in the prolonged sleep group (weekday sleep exceeding optimal duration), longer WRS was linked to an increased nonspecific dementia risk (HR, 1.291; 95% CI 1.087-1.533).ConclusionAdequate WRS can reduce dementia risk, particularly for VaD, after insufficient weekday sleep, highlighting the importance of appropriate WRS for cognitive health.</p>
17 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Cohort Studies
- Dementia
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- Sleep
- Sleep Deprivation
- Time Factors
- UK Biobank
- United Kingdom
10 Authors
- Bo Zhao
- Shaojiong Zhou
- Jie Chang
- Aonan Li
- Chaofan Geng
- Tao Wei
- Yiwei Zhao
- Peiyang Gao
- Zhibin Wang
- Yi Tang
1 Application
| Application ID | Title |
|---|---|
| 92098 | Investigating the genetics, lifestyles, environmental and clinical determinants and their interaction on Aging-Related Diseases |
Enabling scientific discoveries that improve human health