| Title: | Sleep patterns, genetic susceptibility, and gastrointestinal cancer mortality: a large-scale prospective cohort study |
| Journal: | Sleep and Breathing |
| Published: | 18 Sep 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40965708/ |
| DOI: | https://doi.org/10.1007/s11325-025-03452-7 |
Publication 19466
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BackgroundThe impact of sleep patterns on gastrointestinal cancer mortality has not been comprehensively explored. Moreover, the interaction between sleep patterns and genetic susceptibility with gastrointestinal cancer mortality remains uncertain.MethodsThe study included a total of 379 845 participants from the UK Biobank. A poor sleep pattern was defined by short sleep (< 7 h/day) or long sleep (> 9 h/day), late chronotype, frequent insomnia, snoring, and frequent daytime dozing. The outcomes were mortality of any gastrointestinal cancers and six site-specific gastrointestinal cancers. Polygenic risk score was generated to characterize genetic risk. Multivariable cox proportional hazards regression models were use to analyze the associations of sleep patterns and genetic susceptibility with gastrointestinal cancer mortality.ResultsA poor sleep pattern was associated with the increased risk of mortality from overall gastrointestinal cancer (HR 1.32, 95% CI 1.16-1.49), esophagus cancer (HR 1.37, 95% CI 1.02-1.85) and liver cancer (HR 2.01, 95% CI 1.48-2.74). Participants with a poor sleep pattern and high genetic risk combination had the highest mortality risks for esophagus, stomach, colorectal, and liver cancer. Significant multiplicative interactions (HR 1.51, 95% CI 1.05-2.18) and additive interactions (RERI 0.54, 95% CI 0.13-0.95; AP 0.34, 95% CI 0.10-0.58) of an intermediate sleep pattern and high genetic risk were observed on esophagus cancer mortality.ConclusionsA poor sleep pattern is associated with increased risks of gastrointestinal cancer mortality independent of the conventional risk factors, and the association is modified by genetic susceptibility.</p>
13 Keywords
- Adult
- Aged
- Cohort Studies
- Female
- Gastrointestinal Neoplasms
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- Sleep Wake Disorders
- United Kingdom
8 Authors
- Shujuan Lin
- Simeng Gu
- Junpeng Li
- Qinghai Gong
- Yan Zhang
- Feng Tong
- Yanchang Xu
- Danjie Jiang
1 Application
| Application ID | Title |
|---|---|
| 95817 | Sleep health and modifiable lifestyle factors in relation to gastrointestinal disease incidence and mortality |
Enabling scientific discoveries that improve human health