| Title: | Sex- and Ethnic-Specific Associations of Serum Lipids with Risk of 12 Cancers: Findings from 506,381 Adults in Two Large Cohorts |
| Journal: | Antioxidants |
| Published: | 19 Sep 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41009039/ |
| DOI: | https://doi.org/10.3390/antiox14091135 |
Publication 19454
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Abstract
The contribution of serum lipids to carcinogenesis, including their effects on inflammation and oxidative stress, remains debated due to inconsistent evidence across populations. This study aimed to elucidate sex- and ethnic-specific associations between serum lipid indices and the risk of 12 common cancers in two large, distinct populations. We conducted a pooled analysis of 506,381 participants from the UK Biobank (UKB) and the Korean Cancer Prevention Study-II (KCPS-II) cohort, with median follow-ups of 12.0 and 13.0 years, respectively. Multivariable-adjusted Cox hazards models were used to estimate hazard ratios (HRs) for the association between baseline lipids and cancer incidence. In the UKB, a one-standard deviation (1-SD) increase in HDL-C was associated with a decreased overall cancer risk (HR 0.982, 95% CI: 0.969-0.995); meanwhile, a 1-SD increase in LDL-C was associated with an increased risk (HR 1.021, 1.009-1.034); higher HDL-C was linked to an increased risk of cervical cancer (HR 1.167, 1.019-1.337) and prostate cancer (HR 1.025, 1.001-1.049). These associations were not significant in the KCPS-II. The association between serum lipids and cancer risk is substantially modified by sex and ethnicity, suggesting that universal lipid-based prevention strategies may be inappropriate and underscoring the need for population-specific research.</p>
4 Authors
- Minh Nguyen Thien
- Ji Woo Baek
- Yeun Soo Yang
- Sun Ha Jee
1 Application
| Application ID | Title |
|---|---|
| 66486 | Causal inference study to clarify the association between alcohol consumption, diabetes, cancer and cardiovascular disease paradox |
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