| Title: | Prenatal sugar exposure shapes late-life human capital and health |
| Journal: | PNAS Nexus |
| Published: | 20 Sep 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41103576/ |
| DOI: | https://doi.org/10.1093/pnasnexus/pgaf301 |
Publication 19449
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Abstract
Maternal sugar consumption during pregnancy may have a variety of effects on offspring. We exploit the abolishment of the rationing of sweet confectionery in the United Kingdom on 1949 April 24, and its subsequent reintroduction some months later, in an era of otherwise uninterrupted rationing of confectionery (1942-1953), sugar (1940-1953), and many other foods, and we consider effects on late-life cardiovascular disease, body mass index (BMI), height, type-2 diabetes, and the intake of sugar, fat, and carbohydrates, as well as cognitive outcomes and birth weight. We use individual-level data from the UK Biobank for cohorts born between April 1947 and May 1952. We also explore whether one's genetic "predisposition" to the outcome can moderate the effects of prenatal sugar exposure. We find that prenatal exposure to derationing increases education and reduces BMI and sugar consumption at higher ages, in line with the "developmental origins" explanatory framework, and that the sugar effects are stronger for those who are genetically "predisposed" to sugar consumption.</p>
3 Authors
- Gerard J van den Berg
- Stephanie von Hinke
- R Adele H Wang
1 Application
| Application ID | Title |
|---|---|
| 74002 | Developmental Origins: exploring the Nature-Nurture Interplay |
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