| Title: | Lung function as a modifiable risk factor for Ischemic Stroke: Evidence from the UK biobank |
| Journal: | Journal of Stroke and Cerebrovascular Diseases |
| Published: | 25 Sep 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41015216/ |
| DOI: | https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108457 |
Publication 19411
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Abstract
BACKGROUND: Ischemic stroke remains a leading cause of disability and mortality worldwide, with pulmonary function emerging as a potential modifiable risk factor.</p>
METHODS: This study utilizes data from the UK Biobank to explore the association between peak expiratory flow (PEF), a simple and cost-effective marker of lung function, and ischemic stroke risk. A total of 307,827 participants were followed for a median of 13.8 years, with Cox regression models employed to examine the relationship between PEF and ischemic stroke incidence. Restricted cubic splines and mediation analysis were also used to investigate potential nonlinear relationships and the mediating role of inflammatory biomarkers, respectively.</p>
RESULTS: The results demonstrate that individuals with higher PEF levels exhibit a significantly reduced risk of ischemic stroke, with a 6.7 % and 10.4 % lower risk in the second and third tertiles of PEF, respectively, compared to the first tertile.Stratified analyses revealed a significant inverse association between PEF and stroke risk in former smokers (HR = 0.93, 95 %CI:0.88-0.98), with a non-significant trend in current smokers (HR = 0.92, 95 %CI:0.84-1.01). Subgroup analysis revealed heterogeneity by age, gender, hypertension, and diabetes status, highlighting differential effects. Mediation analysis suggested that inflammatory biomarkers, such as the neutrophil-to-lymphocyte ratio, partially mediate the association between lung function and stroke risk.</p>
CONCLUSION: This study underscores the importance of monitoring lung function, particularly at the community level, as a preventive measure against ischemic stroke. Given the aging global population, early detection and management of declining lung function could play a crucial role in reducing stroke-related morbidity and mortality.</p>
18 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Female
- Humans
- Incidence
- Ischemic Stroke
- Lung
- Male
- Middle Aged
- Peak Expiratory Flow Rate
- Prognosis
- Risk Assessment
- Risk Factors
- Smoking
- Time Factors
- UK Biobank
- United Kingdom
8 Authors
- Zihong Bai
- Qingcui Huang
- Xinya Li
- Yitong Ling
- Panwen Wu
- Xiaxuan Huang
- Shanyuan Tan
- Jun Lyu
1 Application
| Application ID | Title |
|---|---|
| 104830 | A Study of influencing factors for cerebrovascular and neurodegenerative diseases |
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