| Title: | Associations of Sleep Pattern and Genetic Risk with Late-Onset Psoriasis: A Large Prospective Cohort Study |
| Journal: | Journal of Investigative Dermatology |
| Published: | 29 Sep 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41033481/ |
| DOI: | https://doi.org/10.1016/j.jid.2025.08.048 |
Publication 19379
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Whether sleep disturbance is associated with the risk of incident psoriasis, and whether this association exists in the presence of different genetic risk levels remain unknown. To examine the sleep-gene interaction in association with risk of psoriasis, we conducted a prospective cohort study that recruited >500,000 participants from 2006 to 2010 using data from the UK Biobank. A sleep pattern was defined by chronotype, sleep duration, insomnia, snoring, and daytime sleepiness and was categorized into 3 groups. In addition, we constructed a weighted genetic risk score of psoriasis and also categorized it into 3 genetic risk groups. We assessed whether there was an interactive effect between the sleep pattern and genetic factors on psoriasis risk. Our results identified that poor sleep pattern was associated with a significantly higher risk of developing psoriasis (hazard ratio = 1.656, 95% confidence interval [CI] = 1.403-1.954, P < .001) compared with ideal sleep pattern, and the effect size was much more pronounced among the female participants (hazard ratio = 2.050, 95% CI = 1.646-2.554, P < .001). The joint effects of sleep pattern and genetic risk was greater in participants with high genetic risk and poor sleep pattern group (hazard ratio = 3.620, 95% CI = 1.671-4.907, P < .001). An interaction effect was detected between sleep pattern and genetic risk, and the population attributable fraction of sleep pattern (49.0%, 95% CI = 40.0-56.6, P < 0.001)) was comparable with genetic risk (50.0%, 95% CI = 44.6-54.8, P < .001)). Altogether, we confirmed that poor sleep pattern increases the risk of incident psoriasis, particularly among the female population.</p>
15 Keywords
- Adult
- Age of Onset
- Aged
- Female
- Genetic Predisposition to Disease
- Humans
- Incidence
- Male
- Middle Aged
- Prospective Studies
- Psoriasis
- Risk Factors
- Sleep
- Sleep Wake Disorders
- United Kingdom
11 Authors
- Yan Zhang
- Yuzhou Huang
- Danrong Jing
- Huaying Liang
- Yuzi Tian
- Guowei Zhou
- Guanxiong Zhang
- Minxue Shen
- Yi Xiao
- Xiang Chen
- Hong Liu
1 Application
| Application ID | Title |
|---|---|
| 55257 | Association of melanoma and non-melanoma skin cancers with the interaction between lifestyle and genetic factors |
Enabling scientific discoveries that improve human health