| Title: | Sugar restriction in the first 1000 days after conception, and long-term respiratory health: a quasi-experiment study |
| Journal: | American Journal of Clinical Nutrition |
| Published: | 1 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41043510/ |
| DOI: | https://doi.org/10.1016/j.ajcnut.2025.09.045 |
Publication 19325
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Abstract
BACKGROUND: High sugar intake during the first 1000 d after conception is common and may impact lifelong respiratory health. Although early-life sugar exposure has been linked to childhood asthma, its long-term effect on adult respiratory disease and lung function is unclear.</p>
OBJECTIVES: This study aims to assess whether restricted sugar intake during the first 1000 d after conception is associated with risk and delayed onset of asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF) in adulthood, and to explore potential mediating mechanisms.</p>
METHODS: We used the cessation of the United Kingdom's sugar rationing in September 1953 as a quasi-experiment, comparing 58,670 UK Biobank participants born 1951-1956 exposed to varying durations of early-life sugar restriction. Participants were classified as exposed (in utero and/or ≤2 y postbirth) or unexposed (born after July 1954). Outcomes included incident asthma, COPD, and IPF (ascertained by health records), validated in the English Longitudinal Study of Ageing (a United Kingdom cohort) and the Health and Retirement Study (a United States cohort). Spirometry indices [forced expiratory volume in 1 s (FEV1)%, forced vital capacity (FVC)%, FEV1/FVC] were measured. Cox models adjusted for demographic, socioeconomic, lifestyle, and clinical factors. Mediation analysis assessed diabetes, hypertension, and birth weight.</p>
RESULTS: Early-life exposure to sugar rationing (in utero plus 1-2 y) was associated with lower risks of asthma [hazard ratio: 0.75; 95% confidence interval (CI): 0.61, 0.91] and COPD [0.73 (0.62, 0.88)], and delayed disease onset by ≤3.6 y. Rationed participants had higher mean FEV1% (increase 6.0; 95% CI: 2.9, 9.1), FVC% [increase 5.9 (3.3, 8.5)], and FEV1/FVC ratio [increase 0.045 (0.011, 0.079)] compared with nonrationed groups. Longer sugar restriction offered greater protection. Diabetes and hypertension mediated 18.2% of the effect; birth weight contributed only 1.6%. Findings were consistent across external validation and placebo analyses.</p>
CONCLUSIONS: Restricting sugar intake during the first 1,000 d after conception was associated with reduced risk and delayed onset of asthma and COPD, and improved lung function in adulthood. These findings support the utility of current dietary guidelines to promote lifelong respiratory health.</p>
13 Keywords
- Adult
- Aged
- Asthma
- Dietary Sugars
- Female
- Humans
- Idiopathic Pulmonary Fibrosis
- Longitudinal Studies
- Male
- Middle Aged
- Pregnancy
- Pulmonary Disease, Chronic Obstructive
- United Kingdom
10 Authors
- Jiazhen Zheng
- Chuang Yang
- Zhen Zhou
- Jinghan Huang
- Qiang Tu
- Haisheng Wu
- Quan Yang
- Wenbo Huang
- Junchun Shen
- Feng Cao
1 Application
| Application ID | Title |
|---|---|
| 97089 | Associations of physical multimorbidity patterns and heart structure with cognition and neuroimaging outcomes |
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