| Title: | A genetic map of human metabolism across the allele frequency spectrum |
| Journal: | Nature Genetics |
| Published: | 3 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41044249/ |
| DOI: | https://doi.org/10.1038/s41588-025-02355-3 |
| URL: | https://www.nature.com/articles/s41588-025-02355-3.pdf |
Publication 19303
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Genetic studies of human metabolism have been limited in scale and allelic breadth. Here we provide a data-driven map of the genetic regulation of circulating small molecules and lipoprotein characteristics (249 traits) measured using proton nuclear magnetic resonance spectroscopy across the allele frequency spectrum in ~450,000 individuals. Trans-ancestral meta-analyses identify 29,824 locus-metabolite associations mapping to 753 regions with effects largely consistent between men and women and large ancestral groups represented in UK Biobank. We observe and classify extreme genetic pleiotropy, identify regulators of lipid metabolism, and assign effector genes at >100 loci through rare-to-common allelic series. We propose roles for genes less established in metabolic control (for example, SIDT2), genes characterized by phenotypic heterogeneity (for example, APOA1) and genes with specific disease relevance (for example, VEGFA). Our study demonstrates the value of broad, large-scale metabolomic phenotyping to identify and characterize regulators of human metabolism.</p>
12 Keywords
- Chromosome Mapping
- Female
- Gene Frequency
- Genetic Pleiotropy
- Genome-Wide Association Study
- Humans
- Lipid Metabolism
- Male
- Metabolomics
- Phenotype
- Polymorphism, Single Nucleotide
- Quantitative Trait Loci
11 Authors
- Martijn Zoodsma
- Carl Beuchel
- Summaira Yasmeen
- Leonhard Kohleick
- Aakash Nepal
- Mine Koprulu
- Florian Kronenberg
- Manuel Mayr
- Alice Williamson
- Maik Pietzner
- Claudia Langenberg
Enabling scientific discoveries that improve human health