| Title: | Small left ventricular size as a predictor for incident type 2 diabetes: insights from the UK biobank cardiovascular magnetic resonance substudy |
| Journal: | Diabetology & Metabolic Syndrome |
| Published: | 3 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41044677/ |
| DOI: | https://doi.org/10.1186/s13098-025-01939-7 |
| URL: | https://dmsjournal.biomedcentral.com/counter/pdf/10.1186/s13098-025-01939-7 |
Publication 19298
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BackgroundLeft ventricular (LV) concentric hypertrophy is common in diabetes patients, presenting as a relatively small LV size. However, studies have shown that a small LV size can also occur in prediabetic conditions without ventricular hypertrophy. We used data from the UK Biobank Cardiovascular Magnetic Resonance Substudy to assess whether a small LV size independently predicts incident type 2 diabetes.Methods and resultsSmall LV size was defined using indexed left ventricular end-diastolic volume (iLVEDV) values (< 56 mL/m² for females and < 57 mL/m² for males). The risk of small LV size for incident type 2 diabetes was assessed using adjusted Cox proportional hazards models. The non-linear relationship between iLVEDV and diabetes risk was evaluated using restricted cubic splines. This study included 35,422 participants, with an average age of 64 years, of whom 53.2% were females. Among the 35,422 participants, 947 (2.7%) had small LV size. During a median follow-up of 698 days, 304 cases of incident type 2 diabetes were recorded. Those with small LV size showed a significant association with increased risk of incident type 2 diabetes (adjusted hazard ratio [HR], 2.36; 95% CI, 1.56-3.57). Subgroup analysis consistently supported this relationship across age, sex, hypertension, obesity, and genetic risk for type 2 diabetes. An L-shaped relationship between iLVEDV and diabetes risk was also observed.ConclusionsSmall LV size is an independent predictor of incident type 2 diabetes, with a smaller LV size correlating with a higher risk of developing the condition, warranting further investigation.Graphical Abstract</p>
7 Authors
- Gaifeng Hu
- Xiaodong Peng
- Liu He
- Zixu Zhao
- Caihua Sang
- Jianzeng Dong
- Changsheng Ma
1 Application
| Application ID | Title |
|---|---|
| 103736 | Metabolism and imaging phenotypes in the prevention and treatment of cardiac arrhythmia and heart failure |
Enabling scientific discoveries that improve human health