| Title: | Association between dietary carbohydrate intake and multiple sclerosis risk: a large-scale cohort study |
| Journal: | Frontiers in Nutrition |
| Published: | 6 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41122503/ |
| DOI: | https://doi.org/10.3389/fnut.2025.1654538 |
| URL: | https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1654538/pdf |
Publication 19281
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Abstract
Introduction: Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by neuroinflammation and demyelination. Although diet may influence MS risk, evidence regarding carbohydrate intake remains unclear.</p>
Methods: We examined this association in a prospective cohort of 210,483 participants from the UK Biobank. Dietary carbohydrates were assessed using repeated 24-hour recalls. The diagnosis of MS cases was based on hospital inpatient records coded with the International Classification of Diseases, 10th Revision (ICD-10) code G35. The association between carbohydrate intake and MS risk was analyzed using Cox proportional hazards models.</p>
Results: Over a median follow-up of 13.25 years, 495 incident MS cases were identified. A per interquartile range (IQR) increase in intake of total carbohydrates (HR = 1.21, 95% CI: 1.05-1.40), total sugars (HR = 1.23, 95% CI: 1.10-1.38), fiber (HR = 1.20, 95% CI: 1.08-1.33), fructose (HR = 1.25, 95% CI: 1.12-1.39), and glucose (HR = 1.20, 95% CI: 1.08-1.34) was associated with an increased risk of MS (all false discovery rate [FDR]-P < 0.05). Restricted cubic spline analyses showed linear dose-response relationships between these five carbohydrate types and MS risk (all Pnonlinear > 0.05). In addition, the associations between these carbohydrates and MS risk exhibited variations across different age and sex subgroups.</p>
Discussion: Our findings indicate that higher carbohydrate intake is associated with an increased risk of MS. Further studies are warranted to elucidate the underlying mechanisms.</p>
12 Authors
- Qi Yuan
- Manli Wang
- Shuhui Chen
- Hao Lin
- Yudan Yang
- Shuyue Zhao
- Baojie Hua
- Jing Guo
- Xiaohui Sun
- Ding Ye
- Jiayu Li
- Yingying Mao
1 Application
| Application ID | Title |
|---|---|
| 113769 | Investigating the complex associations of environmental factors, genetic background, broad phenotypes with the gut-organ axis |
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