| Title: | Wearable device-based health equivalence of different physical activity intensities against mortality, cardiometabolic disease, and cancer |
| Journal: | Nature Communications |
| Published: | 7 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41057301/ |
| DOI: | https://doi.org/10.1038/s41467-025-63475-2 |
| URL: | https://www.nature.com/articles/s41467-025-63475-2.pdf |
Publication 19271
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Abstract
Current conventions, partly derived from self-reported data, typically equate 1 minute of vigorous physical activity (VPA) to 2 minutes of moderate physical activity (MPA). Using accelerometer-derived intensity classification in 73,485 UK Biobank participants (mean follow-up: 8.0 [1.0] years), we assess the equivalence of light activity (LPA) and MPA to 1 minute of VPA for all-cause (ACM) and cardiovascular (CVD) mortality, major adverse cardiovascular events (MACE), type 2 diabetes, and cancer outcomes. For a standardised 5%-35% risk reduction, the median MPA equivalent per minute of VPA is 4.1 (ACM, 95% CI: 4.1-4.2), 7.8 (CVD mortality, 7.7-8.0), 5.4 (MACE, 5.3-5.5), 9.4 (type 2 diabetes, 9.3-9.6), and 3.5 (cancer mortality, 3.4-3.5) minutes. For non-cancer outcomes, the median LPA equivalent per 1 minute of VPA ranges from 53 (ACM) to 94 minutes (type 2 diabetes), reflecting generally weaker dose-response curves of LPA with all outcomes. These findings indicate a substantial departure from self-reported estimates and support integrating device-based equivalence into guidelines and wearables.</p>
13 Keywords
- Accelerometry
- Adult
- Aged
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Exercise
- Female
- Humans
- Male
- Middle Aged
- Neoplasms
- United Kingdom
- Wearable Electronic Devices
6 Authors
- Raaj Kishore Biswas
- Matthew N. Ahmadi
- Adrian Bauman
- Karen Milton
- Nicholas A. Koemel
- Emmanuel Stamatakis
1 Application
| Application ID | Title |
|---|---|
| 25813 | Integrated paradigms to investigate the interplay between lifestyle behaviours, the social environment, and genetic risk in the development of cardio- metabolic disease and mental health. |
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