| Title: | Association between device-measured physical activities, type 2 diabetes, and life expectancy over the next 10 years: a prospective longitudinal study |
| Journal: | BMC Public Health |
| Published: | 9 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41068706/ |
| DOI: | https://doi.org/10.1186/s12889-025-24662-4 |
| URL: | https://bmcpublichealth.biomedcentral.com/counter/pdf/10.1186/s12889-025-24662-4 |
Publication 19239
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Abstract
BackgroundThe mediation effect of 24-hour physical activities on the association between type 2 diabetes and mortality is unclear. Additionally, Little evidence was found on the isotemporal substitution effect of 24-hour physical activities components on changing Life expectancy among patients with type 2 diabetes diagnosed. To address the abovementioned research gap, the study has a two-fold aims: first, to examine the mediation effect of 24-hour physical activities in type 2 diabetes and mortality; and second, to address how reallocating time on different daily activities would affect life expectancy.MethodsAnalysis was conducted on the accelerometer data of 103,359 participants in the UK Biobank, with a median age of 57 years (range 39 to 70). Compositional mediation cox model was conducted to analyze the mediating effects of 24-hour physical activities. Additionally, the cohort Life table method was utilized to estimate the changes of Life-years over the next 10 years resulting from the substitution effect of different physical activities.ResultsDuring a mean follow-up of 13.95 (range 2.95-16.28) years, 2,649 deaths were recorded. Diabetes was significantly associated with increased time spent engaging in sedentary behavior (SB), and reduced time spent on moderate-to-vigorous physical activity (MVPA) and light-intensive physical activity (LPA), thereby demonstrating an association with higher mortality risk. The indirect effect of physical activity (HR = 1.27, 95% CI 1.23-1.30) accounted for 41.9% of the total effect of diabetes on mortality. Furthermore, the Life expectancy gains with a maximum of 1.32 years over the next 10 years was found when reallocating SB time to MVPA.ConclusionThe results revealed that 24-hour physical activities might mediate the association between diabetes and mortality. Therefore, promoting participation in MVPA and reducing sedentary activities among diabetes patients was expected to have a positive effect on Life expectancy over the next 10 years.</p>
13 Keywords
- Accelerometry
- Adult
- Aged
- Diabetes Mellitus, Type 2
- Exercise
- Female
- Humans
- Life Expectancy
- Longitudinal Studies
- Male
- Middle Aged
- Prospective Studies
- United Kingdom
19 Authors
- Ziqiang Lin
- Jiade Chen
- Yutai Cai
- Zhehao Wang
- Jing Xu
- Yingying Shi
- Jiawei Li
- Peng Xu
- Jiaxin Shen
- Guanren Chen
- Qingguang Zhong
- Tao Zhang
- Qiaoman Mo
- Qiaoxuan Lin
- Jiale Bu
- Pengqing Sun
- Lixia Li
- Fan Zhang
- Yanhui Gao
1 Application
| Application ID | Title |
|---|---|
| 90162 | Study on the complex associations of physical and mental diseases with genetics and environment |
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