| Title: | Dietary index for gut microbiota and risk of incident irritable bowel syndrome: a large-scale prospective cohort study |
| Journal: | Nutrition Journal |
| Published: | 9 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41068897/ |
| DOI: | https://doi.org/10.1186/s12937-025-01224-3 |
| URL: | https://nutritionj.biomedcentral.com/counter/pdf/10.1186/s12937-025-01224-3 |
Publication 19224
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Abstract
BackgroundThe novel Dietary Index for Gut Microbiota (DI-GM) quantifies dietary patterns influencing microbiota health, yet its association with irritable bowel syndrome (IBS) risk remains unexplored. We aim to investigate prospective association of DI-GM with incident IBS in a long-term cohort.MethodsParticipants free of IBS at baseline with at least one record of 24-hour dietary recall from UK Biobank were included (N = 175,103). DI-GM was composed of 14 food/nutrient components known to influence gut microbial health. Each component was scored 0 or 1 based on sex-specific median intakes, and total scores were summed. The primary outcome was incident IBS. Multivariable Cox models were used to estimate associated risk.ResultsOver a 12.56-years of follow-up, 2,980 incident IBS cases were identified. Compared to participants with the lowest DI-GM quartile, those with the highest quartile had a 13% lower IBS risk (HR = 0.87; 95% CI: 0.79-0.97; P-value = 0.009), with significant trend (P-trend = 0.012). Moreover, per 1 score increase in DI-GM was associated with a 3% reduced IBS risk (HR = 0.97; 95% CI: 0.95-0.99; P-value = 0.009). Subgroup and sensitivity analyses consistently supported this inverse association.ConclusionsHigher baseline DI-GM scores, reflecting dietary patterns supportive of gut microbiota, are associated with lower risk of developing IBS. These findings suggest that the DI-GM score may serve as a useful predictive tool for assessing IBS risk and facilitating the implementation of targeted dietary interventions. Future studies should examine changes in DI-GM scores over time help establish a potential causal link with IBS.</p>
12 Keywords
- Adult
- Diet
- Female
- Gastrointestinal Microbiome
- Humans
- Incidence
- Irritable Bowel Syndrome
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- United Kingdom
5 Authors
- Yuge Li
- Si Liu
- Qian Zhang
- Shutian Zhang
- Shanshan Wu
1 Application
| Application ID | Title |
|---|---|
| 74444 | Common risk factors and prognosis of inflammatory bowel disease and irritable bowel syndrome |
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