| Title: | Genetic screens of imaging-derived kidney volumes identify genes linked to kidney function |
| Journal: | Kidney International |
| Published: | 10 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41077127/ |
| DOI: | https://doi.org/10.1016/j.kint.2025.08.038 |
| URL: | https://www.kidney-international.org/article/S0085-2538(25)00781-1/pdf |
Publication 19218
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Abstract
INTRODUCTION: Chronic kidney disease (CKD) is defined as sustained abnormalities in kidney function or structure. Genetic studies of CKD have largely focused on kidney function markers such as estimated glomerular filtration rate (eGFR). We hypothesized that genome-wide association studies (GWAS) of magnetic resonance imaging (MRI)-based kidney sub-volumes could provide insights into CKD risk genes complementary to the study of eGFR.</p>
METHODS: Total kidney volume (TKV) and sub-volumes for cortex, medulla, and sinus were derived from abdominal MRIs of 38,816 United Kingdom Biobank participants of European ancestry using a trained convolutional neural network. GWAS was performed for body surface area-normalized kidney volumes and eGFR for comparison. Potentially causal genes at each locus were prioritized using a developed annotation pipeline. We assessed locus overlap between volumes, biomarker-based kidney function, and clinical traits using colocalization analyses. Annotated genes were further characterized through enrichment analyses, molecular and clinical annotations, including a screen for rare, putative loss-of-function variants.</p>
RESULTS: GWAS for 9,803,932 common genetic variants identified 34 significant loci for TKV, 24 for medulla, 26 for cortex, and 71 for sinus, compared to 32 for eGFR. Prioritized genes for cortex and medulla volumes showed corresponding tissue-specific expression and were enriched for kidney development- and hypoxia-related pathways. Genetic effect sizes of significant index single nucleotide polymorphisms for TKV, cortex, and medulla volumes correlated positively with those for eGFR. Some loci such as PKHD1 and BICC1 were strongly associated with kidney volumes but not eGFR. Integration with disease information revealed that rare, putative loss-of-function variants in BICC1, and common variants with regulatory potential, are associated with increased risk for CKD and dialysis, which was not identified in a previous GWAS of eGFR CONCLUSIONS: Our investigation shows that genetic findings of kidney structure can complement kidney function studies and reveal previously unrecognized CKD risk genes in the population.</p>
15 Authors
- Sara Monteiro-Martins
- Yong Li
- Oleg Borisov
- Atlas Khan
- Wilfried Reichardt
- Stefan Haug
- Elias Kellner
- Martin Buechert
- Elisabeth Ott
- Maximilian F Russe
- Fabian Bamberg
- Krzysztof Kiryluk
- Peggy Sekula
- Marco Reisert
- Anna Köttgen
1 Application
| Application ID | Title |
|---|---|
| 41849 | GWAS studies for kidney-related traits using UKBB data. |
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