| Title: | Associations of dietary advanced glycation end products and the risk of depression and anxiety |
| Journal: | European Journal of Nutrition |
| Published: | 15 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41091214/ |
| DOI: | https://doi.org/10.1007/s00394-025-03818-3 |
Publication 19165
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Abstract
PurposeDietary advanced glycation end products (AGEs) might exert adverse effects on mental disorders. To explore whether elevated dietary AGEs intake is associated with increased risk of mental disorders, and whether this association might be affected by genetic risk and allostatic load (AL).MethodsA prospective cohort study, including a total of 112,989 participants, conducted at least two 24-h dietary assessments in the UK Biobank Study (2006-2010) and were followed up until 2021. Dietary AGEs, including Nε-(1-Carboxyethyl)-l-lysine (CEL), Nε-(carboxymethyl) lysine (CML), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated via averaged data from the multiple 24-h food assessments according to the ultra-performance LC-tandem MS based dietary AGEs database. Incident depression and anxiety, ascertained via hospital admission records and mental health questionnaires.ResultsDuring an average follow-up period of 12.9 years, 5489 and 5163 participants developed depression and anxiety, respectively. When comparing high (Q5) quantiles with low quantiles (Q1&2) of dietary AGEs intake, HRs (95%CIs) of depression, anxiety, and mental disorders were 1.16 (1.07, 1.27), 1.11 (1.01, 1.22) and 1.14 (1.07, 1.22), respectively. High dietary CML and MG-H1 intake were also associated increased risk of depression, anxiety, and their co-occurrence. The positive associations between dietary AGEs intake and the risk of depression were more pronounced among participants with intermediate and high genetic risk (P-interaction < 0.001) and with high AL level (P-interaction = 0.019).ConclusionsConsuming high levels of dietary AGEs (including CML and MG-H1) was associated with an increased risk of depression and anxiety. This association may be affected by genetic risk and AL.Graphical abstract</p>
16 Keywords
- Adult
- Aged
- Anxiety
- Cohort Studies
- Depression
- Diet
- Dietary Advanced Glycation End Products
- Female
- Glycation End Products, Advanced
- Humans
- Lysine
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- United Kingdom
10 Authors
- Yebing Zhang
- Huanying He
- Ruoqi Hao
- Fangyuan Jiang
- Xue Li
- Zhengfeei Ma
- Li-Qiang Qin
- Guo-Chong Chen
- Huan-Huan Yang
- Zhongxiao Wan
1 Application
| Application ID | Title |
|---|---|
| 90087 | Role of environmental and host factors and their interplays in the development and progression of chronic diseases |
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