| Title: | Association of cardiometabolic risk burden with gastrointestinal bleeding in aspirin users |
| Journal: | BMC Gastroenterology |
| Published: | 15 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41094370/ |
| DOI: | https://doi.org/10.1186/s12876-025-04347-3 |
| URL: | https://bmcgastroenterol.biomedcentral.com/counter/pdf/10.1186/s12876-025-04347-3 |
Publication 19159
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
IntroductionAspirin is widely used in patients with ischemic cardiovascular diseases, most of whom have cardiometabolic disorders. This study aimed to investigate the impact of cardiometabolic risk burden on first gastrointestinal (GI) bleeding in aspirin users.MethodsThis is a cohort study, including patients with ischemic cardiovascular disease and aspirin prescription from UK biobank. Exposure was cardiometabolic risk burden, calculated as the sum of the presence of cardiometabolic risk factors, including obesity, diabetes, dyslipidemia and hypertension. GI bleeding obtained from hospital inpatient admissions was the outcome. The Cox proportional hazards model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI).ResultsAfter a mean of 13.4 years of follow-up, we found that among 12,781 aspirin users, the incidence rate of GI bleeding was increasing with the growing cardiometabolic risk burden (number of cardiometabolic risk factors from 0 to 4), ranging from 4.53, 4.98, 5.47, 8.08 to 9.64 per 1000 person-years. As compared to participants without cardiometabolic risk factors and after adjustment for potential confounders, the elevated GI risk was greater with the increased burden with HR ranging from 1.09, 1.16, 1.59 to 1.95 (P-trend < 0.001), in which diabetes (HR = 1.24, 95% CI = 1.02-1.51) and hypertension (HR = 1.24, 95% CI = 1.08-1.42) may play a more pronounced role. Stratified analysis found that the association was stronger in those with history of gastrointestinal disorders, younger adults or males.ConclusionsAspirin users with higher burden of cardiometabolic risk experienced significantly higher risk of GI bleeding, calling for concern of tailored strategy for GI bleeding prevention in aspirin users related to cardiometabolic risk burden.</p>
19 Keywords
- Adult
- Aged
- Aspirin
- Cardiometabolic Risk Factors
- Cardiovascular Diseases
- Cohort Studies
- Diabetes Mellitus
- Dyslipidemias
- Female
- Gastrointestinal Hemorrhage
- Humans
- Hypertension
- Incidence
- Male
- Middle Aged
- Obesity
- Proportional Hazards Models
- Risk Factors
- United Kingdom
7 Authors
- Yajing Wei
- Jiamin Yan
- Ziting Gao
- Hongye Wei
- Ziyi Qiu
- Jun Xiao
- Wuqing Huang
1 Application
| Application ID | Title |
|---|---|
| 84352 | Exploring the novel risk factors and therapeutic targets of cardiovascular disease and the role of cardiovascular health in health-related outcomes |
Enabling scientific discoveries that improve human health