| Title: | CCL17 as an Inflammatory Biomarker Enhances Cardiovascular Risk Stratification: a Prospective Cohort Study |
| Journal: | Journal of Cardiovascular Translational Research |
| Published: | 16 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41102544/ |
| DOI: | https://doi.org/10.1007/s12265-025-10714-y |
Publication 19155
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Abstract
Inflammation is a key contributor to cardiovascular disease (CVD), yet existing risk models such as Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) and Pooled Cohort Equations (PCE) inadequately identify individuals at intermediate risk. We investigated whether incorporating the inflammatory chemokine CCL17 could improve cardiovascular risk prediction. In two prospective cohorts - the Shunyi Cohort (n = 706, China) and the UK Biobank (n = 36,097, UK) - baseline CCL17 levels were quantified, and major adverse cardiovascular events (MACEs) were tracked over follow-up. Elevated CCL17 levels were independently associated with increased risk of MACEs. Integrating CCL17 into existing models significantly improved discrimination and reclassification, particularly among intermediate-risk individuals (e.g., NRI: 15.1% in Shunyi; 3.0% in UK Biobank). This biomarker-based refinement enabled earlier identification of clinically significant high-risk individuals. These findings suggest that CCL17 is a promising translational biomarker that may enhance precision prevention by augmenting current cardiovascular risk assessment strategies.Graphical Abstract</p>
9 Authors
- Zeyuan Wang
- Xiaoyu Ren
- Yang Lu
- Jingli Yang
- Jiabo Wu
- Yan Zhang
- Yang Zhang
- Zhuang Tian
- Shuyang Zhang
1 Application
| Application ID | Title |
|---|---|
| 458618 | Unraveling Immunological Mechanisms Underlying Systemic Lupus Erythematosus Combined with Atherosclerotic Cardiovascular Disease |
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