| Title: | Chronic kidney disease is associated with increased risk of sudden cardiac death |
| Journal: | Nature Communications |
| Published: | 16 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41102190/ |
| DOI: | https://doi.org/10.1038/s41467-025-64254-9 |
| URL: | https://www.nature.com/articles/s41467-025-64254-9.pdf |
Publication 19145
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Abstract
Patients with chronic kidney disease (CKD) are recognized as a higher risk group for cardiovascular disease (CVD) due to various traditional risk factors, kidney-specific factors, and comorbidities, which have recently attracted significant attention. However, the long-term risk of acute CVD events such as sudden cardiac death (SCD) in CKD patients is unclear. Using the UK Biobank and Changsha cohorts, we find that CKD is associated with an increased risk of SCD. Patients with early-stage CKD, especially those with advanced CKD, faced an elevated risk of SCD. Furthermore, through proteomic analyses of the UK Biobank and Framingham Offspring Cohort, we identify five candidate proteins (NTproBNP, ANGPT2, FGF23, DTNB, and SEPTIN8) linked to SCD risk in CKD patients. Here, we show that patients with CKD have an increased risk of SCD in the long term, underscoring the imperative for strategies that address both cardiovascular risk and renal function in this population.</p>
18 Keywords
- Adult
- Aged
- Biomarkers
- Cardiovascular Diseases
- Cohort Studies
- Death, Sudden, Cardiac
- Female
- Fibroblast Growth Factor-23
- Fibroblast Growth Factors
- Humans
- Male
- Middle Aged
- Natriuretic Peptide, Brain
- Peptide Fragments
- Proteomics
- Renal Insufficiency, Chronic
- Risk Factors
- United Kingdom
13 Authors
- Yalan Li
- Ruchao Jiang
- Chenxi Ouyang
- Jie Wang
- Qingwei Yu
- Jun Lu
- Wei Hong
- Shiqi Liu
- Yan Chen
- Jingjing Cai
- Hong Yuan
- Li Zhang
- Yao Lu
1 Application
| Application ID | Title |
|---|---|
| 75283 | Modifiable pathways in sex-specific arterial stiffness: Mendelian randomization analysis |
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