| Title: | Associations between triglyceride-glucose-related indices and all-cause and cardiovascular mortality among individuals with atrial fibrillation and metabolic syndrome: a cohort study of the UK biobank |
| Journal: | Cardiovascular Diabetology |
| Published: | 29 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41163015/ |
| DOI: | https://doi.org/10.1186/s12933-025-02963-7 |
| URL: | https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-025-02963-7 |
Publication 19119
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Abstract
BackgroundThe triglyceride-glucose (TyG) related indices are simple biomarkers of insulin resistance and are associated with metabolic syndrome (MetS) and atrial fibrillation (AF). However, whether TyG-related indices are linked to all-cause and cardiovascular mortality in individuals with coexisting AF and MetS remains unclear.MethodsWe included 2535 participants with both AF and MetS from the UK Biobank. TyG-related indices, including TyG, TyG combined with body mass index (TyG-BMI), TyG combined with waist circumference (TyG-WC), and TyG combined with the waist-to-height ratio (TyG-WHtR), were calculated. The study endpoints were all-cause and cardiovascular mortality. Participants were followed until death or December 31, 2023, whichever occurred first. Associations between TyG-related indices and mortality outcomes were assessed using Cox proportional hazards models and restricted cubic spline (RCS) analyses.ResultsOver a mean follow-up period of 12.7 years (IQR: 11.8-15.2), 956 all-cause deaths and 385 cardiovascular deaths were documented. Kaplan-Meier survival analyses revealed the highest incidence of all-cause mortality in the fourth quartile of TyG (log-rank P < 0.001). Compared with individuals in the second quartile, individuals in the highest quartile had a significantly increased risk of all-cause mortality (TyG: hazard ratio (HR) 1.36, 95% confidence interval (CI): (1.14-1.64); TyG-BMI: 1.31, 1.10-1.56; TyG-WC: 1.41, 1.18-1.68; TyG-WHtR: 1.56, 1.3--1.86). Moreover, TyG, TyG-BMI, and TyG-WHtR were significantly associated with cardiovascular mortality (TyG: HR 1.47, 95% CI 1.10-1.95; TyG-WC: 1.41, 1.03-1.93; TyG-WHtR: 1.35, 1.01-1.80). RCS analyses revealed nonlinear association between TyG and mortality and between TyG-BMI and all-cause mortality (all P < 0.05). The results of the sensitivity and subgroup analyses were consistent with those of the primary analyses.ConclusionsThis study demonstrateed the prognostic value of TyG-related indices in individuals with AF and MetS. These indices may serve as practical surrogate markers for risk stratification and the prevention of adverse outcomes.Graphical Abstract</p>
22 Keywords
- Aged
- Atrial Fibrillation
- Biological Specimen Banks
- Biomarkers
- Blood Glucose
- Cause of Death
- Female
- Humans
- Incidence
- Male
- Metabolic Syndrome
- Middle Aged
- Predictive Value of Tests
- Prognosis
- Prospective Studies
- Risk Assessment
- Risk Factors
- Time Factors
- Triglycerides
- UK Biobank
- United Kingdom
- Waist Circumference
9 Authors
- Lei Ding
- Hongda Zhang
- Yuandong Liu
- Zihan Jiang
- Fengyuan Yu
- Yingjie Qi
- Bin Zhou
- Yujing Shen
- Min Tang
1 Application
| Application ID | Title |
|---|---|
| 217390 | Further understanding of cardiovascular and metabolic disorders using large cohort and multimodal data in the UK Biobank |
Enabling scientific discoveries that improve human health