| Title: | Artificial Intelligence-Enhanced Electrocardiography for Complete Heart Block Risk Stratification |
| Journal: | JAMA Cardiology |
| Published: | 1 Nov 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40833775/ |
| DOI: | https://doi.org/10.1001/jamacardio.2025.2522 |
| URL: | https://www.ncbi.nlm.nih.gov/pubmed/40833775 |
Publication 19075
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Abstract
Introduction: Complete heart block (CHB) is a life-threatening condition that can lead to ventricular standstill, syncopal injury, and sudden cardiac death, and current electrocardiography (ECG)-based risk stratification (presence of bifascicular block) is crude and has limited performance. Artificial intelligence-enhanced electrocardiography (AI-ECG) has been shown to identify a broad spectrum of subclinical disease and may be useful for CHB.</p>
Objective: To develop an AI-ECG risk estimator for CHB (AIRE-CHB) to predict incident CHB.</p>
Design, Setting, and Participants: This cohort study was a development and external validation prognostic study conducted at Beth Israel Deaconess Medical Center and validated externally in the UK Biobank volunteer cohort.</p>
Exposure: Electrocardiogram.</p>
Main Outcomes and Measures: A new diagnosis of CHB more than 31 days after the ECG. AIRE-CHB uses a residual convolutional neural network architecture with a discrete-time survival loss function and was trained to predict incident CHB.</p>
Results: The Beth Israel Deaconess Medical Center cohort included 1 163 401 ECGs from 189 539 patients. AIRE-CHB predicted incident CHB with a C index of 0.836 (95% CI, 0.819-0.534) and area under the receiver operating characteristics curve (AUROC) for incident CHB within 1 year of 0.889 (95% CI, 0.863-0.916). In comparison, the presence of bifascicular block had an AUROC of 0.594 (95% CI, 0.567-0.620). Participants in the high-risk quartile had an adjusted hazard ratio (aHR) of 11.6 (95% CI, 7.62-17.7; P < .001) for development of incident CHB compared with the low-risk group. In the UKB UK Biobank cohort of 50 641 ECGs from 189 539 patients, the C index for incident CHB prediction was 0.936 (95% CI, 0.900-0.972) and aHR, 7.17 (95% CI, 1.67-30.81; P < .001).</p>
Conclusions and Relevance: In this study, a first-of-its-kind deep learning model identified the risk of incident CHB. AIRE-CHB could be used in diverse settings to aid in decision-making for individuals with syncope or at risk of high-grade atrioventricular block.</p>
11 Keywords
- Aged
- Artificial Intelligence
- Cohort Studies
- Electrocardiography
- Female
- Heart Block
- Humans
- Male
- Middle Aged
- Prognosis
- Risk Assessment
15 Authors
- Arunashis Sau
- Henry Zhang
- Joseph Barker
- Libor Pastika
- Konstantinos Patlatzoglou
- Boroumand Zeidaabadi
- Ahmed El-Medany
- Gul Rukh Khattak
- Kathryn A. McGurk
- Ewa Sieliwonczyk
- James S. Ware
- Nicholas S. Peters
- Daniel B. Kramer
- Jonathan W. Waks
- Fu Siong Ng
Enabling scientific discoveries that improve human health