| Title: | The Genetic Architecture of the Human Corpus Callosum and its Subregions |
| Journal: | Nature Communications |
| Published: | 4 Nov 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41188267/ |
| DOI: | https://doi.org/10.1038/s41467-025-64791-3 |
| URL: | https://www.nature.com/articles/s41467-025-64791-3.pdf |
Publication 19031
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Abstract
The corpus callosum (CC) is the largest set of white matter fibers connecting the two hemispheres of the brain. In humans, it is essential for coordinating sensorimotor responses and performing associative or executive functions. Identifying which genetic variants underpin CC morphometry can provide molecular insights into the CC's role in mediating cognitive processes. We developed and used an artificial intelligence based tool to extract the midsagittal CC's total and regional area and thickness in two large public datasets. We performed a genome-wide association study (GWAS) meta-analysis of European participants (combined N = 46,685) with generalization to the non-European participants (combined N = 7040). Post-GWAS analyses implicated prenatal intracellular organization and cell growth patterns, and high heritability in regions of open chromatin. Results suggest programmed cell death mediated by the immune system drives the thinning of the posterior body and isthmus. Genetic overlap, and causal genetic liability, between the CC, cerebral cortex features, and neuropsychiatric disorders such as attention-deficit/hyperactivity, bipolar disorders, and Parkinson's disease were identified.</p>
12 Keywords
- Adult
- Bipolar Disorder
- Corpus Callosum
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Parkinson Disease
- Polymorphism, Single Nucleotide
13 Authors
- Ravi R. Bhatt
- Shruti P. Gadewar
- Ankush Shetty
- Iyad Ba Gari
- Elizabeth Haddad
- Shayan Javid
- Abhinaav Ramesh
- Elnaz Nourollahimoghadam
- Alyssa H. Zhu
- Christiaan de Leeuw
- Paul M. Thompson
- Sarah E. Medland
- Neda Jahanshad
1 Application
| Application ID | Title |
|---|---|
| 11559 | Enhancing Neuro Imaging Genetics through Meta Analysis |
Enabling scientific discoveries that improve human health