| Title: | Associations of Integrated Left Ventricular Myocardial Strain Metrics and Incident Atrial Fibrillation |
| Journal: | CJC Open |
| Published: | 21 Nov 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41836124/ |
| DOI: | https://doi.org/10.1016/j.cjco.2025.11.012 |
| URL: | https://www.cjcopen.ca/article/S2589-790X(25)00694-8/pdf |
Publication 18836
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Abstract
Background: Data on associations between left ventricular (LV) strain metrics and incident atrial fibrillation (AF) remains limited, particularly regarding integrated effects of multi-directional strains. This study aimed to investigate the associations of LV global longitudinal strain (GLS), radial strain (GRS) and circumferential strain (GCS) measured by cardiac magnetic resonance with incident AF.</p>
Methods: This prospective cohort study included 36,876 AF-free UK Biobank participants (52.5% female; median age 64.0 years). Incident AF was ascertained via ICD-10 codes. Impaired strain metrics were defined as the absolute value of lower 5%. Cox proportional hazards regression (adjusting for demographic characteristics, lifestyle factors, cardiac imaging indices, and clinical features) was performed to assess the associations of LV strain metrics and incident AF.</p>
Results: Over 6.88 ± 1.63 years, 862 incident AF events occurred. GLS (HR 1.22, 95%CI 1.13-1.31), GRS (0.88, 0.80-0.96), and GCS (1.27, 1.15-1.40) were independently associated with AF (all P < 0.01), with J-shaped (GLS/GCS) and reverse J-shaped (GRS) nonlinearity. AF risk increased with the number of impaired strain metrics (P trend < 0.001), more pronounced in ≥ 60 years (HR 1.45 for single, 1.87 for two, 3.36 for three impairments), while <60 years only showed significance with all three impaired (HR 4.09, 95%CI 1.35-12.36).</p>
Conclusion: LV GLS, GRS, and GCS are linked to incident AF. Combined strain impairment improves AF risk stratification, especially in adults ≥ 60 years.</p>
8 Authors
- Chi Yuan
- Qie Zhang
- Yuhao Hu
- Yangjing Xie
- Xijun Gong
- Xiaochen Wang
- Feilong Zhang
- Ronghui Yu
1 Application
| Application ID | Title |
|---|---|
| 280417 | Comorbidity and lifestyle on the outcome of cardiovascular diseases |
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