| Title: | Prospective association of the triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol ratio with anxiety risk in a community-based cohort: a UK Biobank study |
| Journal: | BMJ Open |
| Published: | 24 Nov 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41290299/ |
| DOI: | https://doi.org/10.1136/bmjopen-2025-103997 |
| URL: | https://bmjopen.bmj.com/content/bmjopen/15/11/e103997.full.pdf |
Publication 18823
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Abstract
OBJECTIVE: To investigate whether the triglyceride-glucose (TyG) index and the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio, as clinical surrogates of insulin resistance, predict the risk of anxiety, and to examine the potential mediating role of plasma proteins.</p>
DESIGN: Prospective cohort study.</p>
SETTING: Community-based population cohort in the United Kingdom.</p>
PARTICIPANTS: A total of 412 767 participants aged 40-69 years without anxiety at baseline and with available data on TyG index and TG/HDL-C ratio were included. Among them, 43 991 participants had proteomic data with 2923 unique plasma proteins measured.</p>
PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was the incidence of first-episode anxiety. The main exposures were TyG index and TG/HDL-C ratio. Mediation analysis was conducted to assess the contribution of plasma proteins.</p>
RESULTS: During a median follow-up of 13.8 years, 21 616 cases of first-episode anxiety were identified. Higher quintiles of TyG index and TG/HDL-C ratio were significantly associated with increased anxiety risk (p trend <0.001). Each one SD increase in TyG index and TG/HDL-C ratio was associated with an 8% and 9% higher risk of anxiety, respectively. Mediation analysis showed that 36 proteins jointly explained 64.0% and 74.9% of the associations of TyG index and TG/HDL-C ratio with anxiety, respectively, with asialoglycoprotein receptor 1 (ASGR1) and protease serine 8 (PRSS8) identified as key mediators.</p>
CONCLUSIONS: Elevated baseline TyG index and TG/HDL-C ratio are associated with an increased risk of anxiety, and this association may be mediated by ASGR1 and PRSS8.</p>
17 Keywords
- Adult
- Aged
- Anxiety
- Biological Specimen Banks
- Biomarkers
- Blood Glucose
- Cholesterol, HDL
- Female
- Humans
- Insulin Resistance
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- Triglycerides
- UK Biobank
- United Kingdom
5 Authors
- Huiming Ren
- Tian Zhao
- Zhongyue Lv
- Guoming Xie
- Hongpeng Sun
1 Application
| Application ID | Title |
|---|---|
| 78619 | Comprehensive investigation into the relationship of genetic and environmental factors with metabolic diseases and cancer |
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