| Title: | Study Protocol for HeartMagic: A Prospective Observational Cohort Characterizing Subtypes of Heart Failure With Preserved Ejection Fraction |
| Journal: | Journal of the American Heart Association |
| Published: | 11 Dec 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41378481/ |
| DOI: | https://doi.org/10.1161/jaha.125.043541 |
Publication 18777
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Abstract
BACKGROUND: Heart failure (HF) is a life-threatening syndrome with significant morbidity and mortality. Although evidence-based drug treatments have effectively reduced morbidity and mortality in HF with reduced ejection fraction (EF), few therapies have been demonstrated to improve outcomes in HF with preserved EF. This may be caused by the existence of several HF with preserved EF subtypes that each need different treatments. There is therefore an unmet need for a comprehensive approach to subtype patients with HF with preserved EF. This protocol details the approach employed in the HeartMagic (Heart Failure Studied With a Machine Learning, Genomics, and Imaging Combination) study to address this gap.</p>
METHODS: This prospective multicenter observational cohort study will include 500 consecutive patients with HF with preserved EF at 2 Swiss university hospitals, along with 50 age-matched patients with HF with reduced EF and 50 healthy controls. In addition to routine clinical workup, participants undergo genomic, transcriptomic, and metabolomic analyses, and the anatomy, composition, and function of the heart are quantified by comprehensive echocardiography and magnetic resonance imaging. Quantitative magnetic resonance imaging is also applied to characterize the kidney. The primary outcome is a composite of 1-year cardiovascular mortality or rehospitalization. Machine learning-based multimodal clustering will be employed to identify distinct HF with preserved EF subtypes. Statistical analysis will include group comparisons, survival analysis, and integrative multimodal clustering combining clinical, imaging, ECG, genomic, transcriptomic, and metabolomic data to identify and validate HF with preserved EF subtypes.</p>
CONCLUSIONS: The integration of comprehensive magnetic resonance imaging with extensive genomic and metabolomic profiling in this study will result in an unprecedented panoramic view of HF with preserved EF and help distinguish functional subgroups, which may provide a basis for personalized therapies.</p>
16 Keywords
- Aged
- Echocardiography
- Female
- Genomics
- Heart Failure
- Humans
- Machine Learning
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Multicenter Studies as Topic
- Observational Studies as Topic
- Prospective Studies
- Stroke Volume
- Switzerland
- Ventricular Function, Left
21 Authors
- Philippe Meyer
- Angela Rocca
- Jaume Banus
- Augustin C. Ogier
- Costa Georgantas
- Pauline Calarnou
- Anam Fatima
- Jean-Paul Vallée
- Jean-François Deux
- Aurélien Thomas
- Julien Marquis
- Pierre Monney
- Henri Lu
- Alessandra Pia Porretta
- Jean-Baptiste Ledoux
- Cloé Tillier
- Lindsey A Crowe
- Tamila Abdurashidova
- Jonas Richiardi
- Roger Hullin
- Ruud B. van Heeswijk
1 Application
| Application ID | Title |
|---|---|
| 80108 | finding subtypes of heart failure with preserved ejection fraction using imaging genetics and machine learning on graphs |
Enabling scientific discoveries that improve human health