| Title: | Protocol: Estimating cross-ancestry local genetic correlation using Logica |
| Journal: | STAR Protocols |
| Published: | 24 Dec 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41447520/ |
| DOI: | https://doi.org/10.1016/j.xpro.2025.104299 |
Publication 18774
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Abstract
Here, we present a reproducible protocol for estimating cross-ancestry local genetic correlation using Logica, a likelihood-based framework that employs summary statistics from genome-wide association studies (GWASs) and ancestry-specific linkage disequilibrium (LD). We describe steps for estimating locus-level heritability and cross-ancestry genetic correlation and outlining required inputs. We then detail analytical procedures to enable accurate and scalable inference of shared genetic architecture. For complete details on the use and execution of this protocol, please refer to Gao et al.1.</p>
3 Authors
- Boran Gao
- Zheng Li
- Xiang Zhou
1 Application
| Application ID | Title |
|---|---|
| 30186 | Novel Methods to Jointly Analyze Pleiotropic Genetic Effects on Multiple Traits Integrating Epigenomics and Genomics Data |
Enabling scientific discoveries that improve human health