| Title: | Lipoprotein(a) Is Associated With Increased Risk of Abdominal Aortic Aneurysm |
| Journal: | JACC Basic to Translational Science |
| Published: | 6 Jan 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41500124/ |
| DOI: | https://doi.org/10.1016/j.jacbts.2025.101457 |
Publication 18729
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Abstract
Lp(a) is a genetically determined lipoprotein targeted by emerging therapies. In a UK Biobank analysis (1,026 abdominal aortic aneurysm [AAA] cases, 469,989 controls), elevated Lp(a) was associated with increased risk of AAA, including at clinically relevant thresholds while controlling for traditional risk factors, including ApoB. Multivariable Mendelian randomization confirmed a causal relationship between lipoprotein(a) [Lp(a)] and AAA independent of apolipoprotein B. These findings support Lp(a) as a modifiable risk factor and potential therapeutic target for AAA, a condition with limited medical treatment options. AAA should be considered as an outcome in future clinical trials of Lp(a)-lowering therapies.</p>
9 Authors
- Pranav Sharma
- Renae Judy
- Shuai Yuan
- Corry Gellatly
- Katie L. Saxby
- Daniel J. Rader
- Matthew J. Bown
- Michael G. Levin
- Scott M. Damrauer
1 Application
| Application ID | Title |
|---|---|
| 70653 | Common and rare genetic variants associated with cardiometabolic traits and disease |
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