| Title: | Biological aging and incident cardiovascular diseases in individuals with diabetes: insights from a large prospective cohort study |
| Journal: | Cardiovascular Diabetology |
| Published: | 6 Aug 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40770719/ |
| DOI: | https://doi.org/10.1186/s12933-025-02855-w |
| URL: | https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-025-02855-w |
Publication 18723
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Abstract
BackgroundBiological aging is a critical risk factor of age-related diseases, but its impact on diabetic individuals remains unclear. This study aimed to examine the associations of biological aging with the incident cardiovascular diseases (CVDs) and life expectancy loss in diabetic individuals.MethodsWe included 12,828 diabetic individuals in UK biobank. Biological aging was calculated by Klemera-Doubal method Biological Age (KDMAge) and phenotypic age (PhenoAge). Cox proportional hazard models were fitted to investigate the associations of biological aging with incident coronary heart disease (CHD), atrial fibrillation (AF), heart failure (HF), stroke, and degenerative valvular heart disease (VHD) in diabetic individuals. We also evaluated life expectancy loss in accelerated aging individuals, the interactions between biological aging and clonal hematopoiesis of indeterminate potential (CHIP), and performed causal mediation analysis.ResultsDuring a median follow-up of 13.1 years, we documented 3794 incident CVDs in diabetic individuals. PhenoAge accelerated aging was significantly associated with all CVD subtypes, with hazard ratios ranging from 1.23 to 1.62, and KDMAge showed even stronger associations. Accelerated biological aging was also associated with over 2 years of life expectancy loss. CHIP and PhenoAge accelerated aging had a significant synergistic effect on CHD, HF, and VHD. Inflammatory activation contributed significantly to accelerated aging-associated CHD and HF.ConclusionsBiological aging significantly increases CVD risk and reduces life expectancy in diabetic population, with effects modified by CHIP status. Targeting biological aging mechanisms may help prevent CVDs and premature mortality in diabetic population.Graphical abstractAF, atrial fibrillation; CHD, coronary heart disease; CHIP, clonal hematopoiesis of indeterminate potential; CI, confidence interval; CVD, cardiovascular disease; HF, heart failure; HR, hazard ratio; KDMAge, Klemera-doubal method biological age; PAR, partial population attributable risk; PhenoAge, phenotypic age; VHD, valvular heart disease.</p>
19 Keywords
- Age Factors
- Aged
- Aging
- Cardiovascular Diseases
- Clonal Hematopoiesis
- Diabetes Mellitus
- Female
- Humans
- Incidence
- Life Expectancy
- Male
- Middle Aged
- Phenotype
- Prognosis
- Prospective Studies
- Risk Assessment
- Risk Factors
- Time Factors
- United Kingdom
8 Authors
- Zhiwei Zeng
- Chunyu Yu
- Runze Chen
- Zhongchen Li
- Peng Wang
- Xueying Wang
- Xi Li
- Zhe Zheng
1 Application
| Application ID | Title |
|---|---|
| 87841 | Genetic Determinants and Gene-Environment Interactions of Cardiovascular Disease and Cardiometabolic Risk Factors |
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