| Title: | Associations of Moderate-to-Vigorous Physical Activity Timing With Type 2 Diabetes Incidence in UK Biobank and Prevalent Glycemic Measures in NHANES. |
| Journal: | Diabetes Care |
| Published: | 9 Jan 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41511492/ |
| DOI: | https://doi.org/10.2337/dc25-2095 |
| URL: | https://diabetesjournals.org/care/article-pdf/doi/10.2337/dc25-2095/853620/dc252095.pdf |
Publication 18668
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Abstract
OBJECTIVE: We assessed the association between timing of moderate-to-vigorous physical activity (MVPA) with incident type 2 diabetes (T2D) and glycemic measures.</p>
RESEARCH DESIGN AND METHODS: Regression models were used to assess associations between accelerometer-derived MVPA timing and incident T2D in UK Biobank (UKB) (n = 84,528, prospective), prevalent diabetes, and glycemic measures in the National Health and Nutrition Examination Survey (NHANES) (n = 6,998, cross-sectional).</p>
RESULTS: In UKB, with early morning (0500-0959) MVPA as reference and before adjustment for total MVPA, "variable-timing" MVPA was associated with the lowest incident T2D risk; while after adjustment, afternoon-evening MVPA (1500-2400) showed the lowest incident T2D risk. In NHANES, afternoon/early evening MVPA was weakly associated with more favorable glycemic measures and lower diabetes prevalence after adjustment for total MVPA.</p>
CONCLUSIONS: When keeping total MVPA volume constant, clustering MVPA in the afternoon-evening was associated with the strongest reduction in incident T2D risk, fewer prevalent diabetes, and more favorable glycemic measures.</p>
13 Authors
- Qiuyu Feng
- Gali Albalak
- Linjun Ao
- Qian Xiao
- Heming Wang
- Jeroen H P M van der Velde
- Jessica C Kiefte-de Jong
- Martin K Rutter
- Charles E Matthews
- Joshua R Freeman
- Ko Willems van Dijk
- Diana van Heemst
- Raymond Noordam
1 Application
| Application ID | Title |
|---|---|
| 81423 | Multidimensional role of sleep and circadian rhythm in lifestyle exposures in the development of age-related diseases |
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