| Title: | Marine n-3 fatty acids protect against renal function deterioration in diabetic patients by modulating lipoproteins and promoting cholesterol efflux |
| Journal: | Journal of Advanced Research |
| Published: | 10 Feb 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41679602/ |
| DOI: | https://doi.org/10.1016/j.jare.2026.02.001 |
Publication 18313
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
INTRODUCTION: Marine n-3 polyunsaturated fatty acids (PUFAs) are proposed to have ameliorative effects on kidney function, but their role in type 2 diabetes (T2D)-related kidney disease remains uncertain.</p>
OBJECTIVES: In this study, we assessed the protective effect of marine n-3 PUFAs against worsening renal function in T2D patients and explored the underlying mechanisms.</p>
METHODS: Individuals with T2D in UK biobank were included to examine associations between circulating fatty acids and incident chronic kidney disease (CKD). The PNMD trial (NCT03708887) is a 14-month randomized, double-blind, placebo-controlled trial evaluating dose-dependent effects of marine n-3 PUFAs on renal function in T2D.</p>
RESULTS: In a cohort of 5,856 diabetic patients, higher plasma levels of n-3 PUFAs were associated with a 22% reduction in the risk of developing CKD. RCT involving 415 T2D patients reported that high-dose n-3 PUFA (3 g/day) supplementation significantly improved estimated glomerular filtration rate (eGFR) compared with placebo. The protective effect of n-3 PUFA supplementation against worsening renal function among T2D patients was primarily mediated by HDL-4-Apo-A2, a key subclass of high-density lipoproteins and was more pronounced in patients with the Apo-A1 related rs10419198 TT/CT genotype. Using the db/db/fat-1 transgenic mice, we unraveled endogenous n-3 PUFAs advances renal function by modulating lipid metabolism and promoting cholesterol efflux through the Sirt1-PGC1α-ABCA1 pathway.</p>
CONCLUSION: These findings provide novel insights into the protective role of marine n-3 PUFAs in preserving impaired kidney function in T2D, underscoring their potential as a therapeutic strategy for diabetic kidney disease.</p>
20 Authors
- Xuzhi Wan
- Pan Zhuang
- Xunan Lin
- Hao Ye
- Yang Ao
- Xiaohui Liu
- Qi Lu
- Wei Jia
- Weifang Zheng
- Weiming Chen
- Yin Li
- Xiaochun Lan
- Haoyu Li
- Wenzhou Tong
- Yuqi Wu
- Denghui Meng
- PNMD-Trial Group
- Yu Zhang
- Chao Zheng
- Jingjing Jiao
1 Application
| Application ID | Title |
|---|---|
| 47365 | Dietary patterns and genetic predisposition to obesity, type 2 diabetes, and cardiovascular disease. |
Enabling scientific discoveries that improve human health