| Title: | [Metabolic dysfunction-associated fatty liver disease, metabolic dysfunction-associated steatotic liver disease and clinically diagnosed osteoarthritis: a prospective cohort study]. |
| Journal: | Chinese Journal of Epidemiology |
| Published: | 10 Feb 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41765660/ |
| DOI: | https://doi.org/10.3760/cma.j.cn112338-20250606-00381 |
Publication 18309
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Abstract
Objective: We aimed to comprehensively assess the impact of metabolic dysfunction-associated fatty liver disease (MAFLD) and metabolic dysfunction-associated steatotic liver disease (MASLD) on the incidence of clinically diagnosed knee, hip, and hand osteoarthritis (OA). Methods: This prospective study analyzed data from 350 273 participants in the United Kingdom Biobank, with outcomes including all-cause OA, knee, hip, and hand OA, and polyarthrosis. Multivariable Cox proportional hazards regression models were used to estimate the association. Results: A total of 131 821 (37.6%) participants had MAFLD, and 102 110 (29.2%) had MASLD. MAFLD was associated with a higher risk of total OA (HR=1.72, 95%CI: 1.68-1.75). There are different OA risks among MAFLD subtypes: overweight and metabolic dysfunction subtypes increase the risk of total OA (HR=1.75, 95%CI: 1.71-1.79), whereas lean metabolism disorder subtypes are not associated with OA in any body part. MASLD (HR=1.57, 95%CI: 1.54-1.60) was associated with a higher risk of total OA, and the association became more prominent with increasing alcohol intakes. The effect of MAFLD on OA was consistent regardless of the presence of MASLD. Conclusions: MAFLD and MASLD are associated with an increased risk of OA, especially for knee OA. Obesity and alcohol intake play a key driving role in the association of steatotic liver disease with OA.</p>
13 Keywords
- Adult
- Aged
- Fatty Liver
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Osteoarthritis
- Osteoarthritis, Knee
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
10 Authors
- Z S Liang
- W H Gao
- Z R Zhang
- H Z Jin
- R F Li
- X M Hu
- Z T Liu
- X Y Li
- Y Cheng
- Y W Liu
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