| Title: | Association of composite dietary antioxidant index with incidence and mortality of aortic aneurysm and dissection: insights from the UK Biobank |
| Journal: | Frontiers in Nutrition |
| Published: | 13 Feb 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41769637/ |
| DOI: | https://doi.org/10.3389/fnut.2026.1713690 |
| URL: | https://public-pages-files-2025.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1713690/pdf |
Publication 18255
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Abstract
Background: The composite dietary antioxidant index (CDAI) is a scoring system designed to assess overall dietary antioxidant capacity and has been associated with a reduced risk of cardiovascular diseases. However, its specific impact on aortic aneurysm and dissection (AA/AD) remains unclear. This study aimed to investigate the associations of CDAI with both the incidence and mortality of AA/AD.</p>
Methods: In this UK Biobank-based study, univariate and multivariate logistic regression models were used to assess the association between CDAI and the incidence of AA/AD, the association of CDAI with mortality was evaluated using Cox proportional hazards models. We employed restricted cubic spline (RCS) analyses to examine potential linear or non-linear relationships between the key nutrient components of the CDAI and the outcomes. Furthermore, mediation analysis was performed to assess the potential mediating effects of selected metabolic indicators.</p>
Results: A total of 172,450 participants were included in this study, of whom 1,486 developed AA/AD. Univariate logistic regression analysis revealed a significant inverse association between CDAI and the incidence of AA/AD (OR = 0.93, 95% CI: 0.88-0.99, p = 0.024). A significantly lower risk of AA/AD mortality was observed in participants within the highest quartile of CDAI compared to those in the lowest quartile (HR = 0.83, 95% CI: 0.71-0.96, p = 0.018), based on the Cox regression analysis. RCS analysis indicated a linear relationship between CDAI and the mortality of AA/AD (P for overall < 0.001; P for nonlinear > 0.05). Furthermore, mediation analysis suggested that uric acid, neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP), and high-density lipoprotein cholesterol (HDL-C) mediated the association between CDAI and AA/AD incidence.</p>
Conclusion: This study supports the pathogenic role of oxidative stress and inflammation in AA/AD, demonstrating that a higher CDAI is associated with lower incidence and mortality of AA/AD in a UK-based adult population. These findings provide new insights, suggesting that dietary antioxidant intervention could serve as a potential preventive strategy against these conditions.</p>
7 Authors
- Shengwei Lai
- Handai Qin
- Minghao Liu
- Zhiwei Lai
- Shuaifei Ji
- Dan Rong
- Wei Guo
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