| Title: | TRPM3 mediates spontaneous pain and mechanical allodynia in a mouse model of chronic orofacial neuropathy |
| Journal: | Cell Reports Medicine |
| Published: | 9 Mar 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41806836/ |
| DOI: | https://doi.org/10.1016/j.xcrm.2026.102645 |
Publication 18237
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Abstract
Trigeminal nerve injury can lead to chronic and difficult-to-treat orofacial neuropathic pain. Here, we uncover a key role for the cation channel TRPM3 in the chronic constriction injury of the infraorbital nerve (IoN-CCI) mouse model of trigeminal neuropathic pain. Wild-type (WT) mice develop spontaneous pain and mechanical allodynia for up to 6 weeks following IoN-CCI, whereas Trpm3-/- mice do not develop such symptoms. Using longitudinal RNA sequencing (RNA-seq) analysis, we obtain a detailed time course of transcriptome alterations in trigeminal ganglia during progression of the IoN-CCI model; notably, gene expression regulation is not different between WT and Trpm3-/- mice. Two structurally distinct TRPM3 antagonists, primidone and isosakuranetin, effectively reverse spontaneous pain and mechanical allodynia, whereas mavatrep, a potent TRPV1 antagonist, is without analgesic effect. These data indicate that TRPM3 is essential for ongoing pain and allodynia following trigeminal nerve injury, making it a potential target for treating trigeminally mediated neuropathic pain.</p>
12 Keywords
- Animals
- Disease Models, Animal
- Facial Pain
- Hyperalgesia
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Neuralgia
- TRPM Cation Channels
- Trigeminal Ganglion
- Trigeminal Nerve Injuries
13 Authors
- Kristof Deseure
- Ilhem Dallali
- Silvia Pinto
- Katrien Luyten
- Andrei Segal
- Nele Van Ranst
- Robbe Roelens
- Sean Corbett
- Stuart Murray
- Eleonora Persoons
- Guy Hans
- Joris Vriens
- Thomas Voets
1 Application
| Application ID | Title |
|---|---|
| 103552 | Understanding the Impact of Common and Rare Genetic Variants on the Penetrance and Pathogenicity of Human Neurological Disorders |
Enabling scientific discoveries that improve human health