| Title: | Oxidative balance score, inflammatory biomarkers, and risk of psychiatric disorders and suicide attempts: A prospective cohort study |
| Journal: | Journal of Affective Disorders |
| Published: | 23 Mar 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41881111/ |
| DOI: | https://doi.org/10.1016/j.jad.2026.121672 |
Publication 18229
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Abstract
BACKGROUND: Oxidative stress and inflammation contribute to psychiatric disorders and suicide attempt (SA), yet the prospective associations of a comprehensive oxidative balance score (OBS) with these outcomes, and the mediating role of inflammatory biomarkers, remain unclear.</p>
METHODS: This study included 143,851 UK Biobank participants with complete data and free of psychiatric disorders and SA at baseline. We constructed an OBS from 16 dietary (DOBS) and 4 lifestyle (LOBS) components. Cox models assessed associations with incident anxiety, depression, substance use disorder (SUD), schizophrenia (SCZ), bipolar disorder (BD), and SA. Mediation analyses evaluated inflammatory biomarkers.</p>
RESULTS: Over 13.1 years of median follow-up, 13,448 participants developed psychiatric disorders (4966 anxiety; 4580 depression; 5941 SUD; 48 SCZ; 107 BD; 225 SA). Compared with the lowest quartile, the highest OBS quartile showed markedly lower risks of any psychiatric disorder and SA (HR: 0.58, 95% CI: 0.54-0.61). Higher DOBS and LOBS also showed protective associations. For individual outcomes, higher OBS was linked to reduced risks of anxiety (HR: 0.87, 95% CI: 0.80-0.95), depression (HR: 0.75, 95% CI: 0.68-0.82), SUD (HR: 0.30, 95% CI: 0.27-0.33), and SA (HR: 0.55, 95% CI: 0.34-0.89) after FDR correction, with a non-significant trend for SCZ and BD. Inflammatory biomarkers significantly mediated these associations, explaining 0.22%-11.65% of the associations.</p>
CONCLUSIONS: Higher OBS, DOBS, and LOBS were associated with lower risks of psychiatric disorders and SA, partly through inflammatory biomarkers. Antioxidant-oriented diet and lifestyle patterns may support long-term mental health.</p>
17 Keywords
- Adult
- Aged
- Biomarkers
- Bipolar Disorder
- Female
- Humans
- Inflammation
- Life Style
- Male
- Mental Disorders
- Middle Aged
- Oxidative Stress
- Prospective Studies
- Risk Factors
- Schizophrenia
- Suicide, Attempted
- United Kingdom
11 Authors
- Yichun Wu
- Yuheng Yuan
- Xiaomai Zhou
- Shufan Duan
- Yangqian Chu
- Linzhou Zhu
- Yinda Zhu
- Xin Yang
- Jun Wu
- Yueping Shen
- Jingting Jiang
1 Application
| Application ID | Title |
|---|---|
| 68136 | Prediction of the risk of morbidity, recurrence and mortality of cardiovascular diseases and cancer: the effect of environmental, clinical and genetic factors |
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