| Title: | Association Between Questionnaire- and Accelerometer-Based Physical Activity and Abdominal Aortic Aneurysm Incidence. |
| Journal: | Journal of the American Heart Association |
| Published: | 25 Mar 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41878859/ |
| DOI: | https://doi.org/10.1161/jaha.125.043217 |
Publication 18207
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Abstract
BACKGROUND: While physical activity (PA) may influence abdominal aortic aneurysm (AAA) risk, prior studies relied on self-reported data, and genetic interactions remain unexplored. We investigated PA and AAA associations using accelerometer and questionnaire data and assessed genetic predisposition.</p>
METHODS: We included 392 737 UK Biobank participants with questionnaire-based PA data and 92 101 with accelerometer-based data, all free of baseline AAA. PA was categorized into light-intensity, moderate-intensity, vigorous-intensity, moderate- to vigorous-intensity, and total PA. Incident AAA was ascertained using International Classification of Diseases, Tenth Revision (ICD-10), and Office of Population, Censuses and Surveys Classification of Interventions and Procedures (OPCS-4) codes. Dose-response associations were examined using restricted cubic splines. Genetic susceptibility was assessed using polygenic risk scores. Associations were estimated using Cox proportional hazards models and isotemporal substitution models.</p>
RESULTS: Among cohorts with questionnaire- (n=392 737; median follow-up, over 13.5 years) and accelerometer- (n=92 101; median follow-up, 7.9 years) based PA data, there were 2181 and 402 incident cases, respectively. Higher moderate-intensity PA, vigorous-intensity PA, and total PA were inversely associated with AAA risk. Protective associations were strongest in patients with low genetic risk and high PA. A nonlinear relationship was observed for moderate-intensity PA and moderate- to vigorous-intensity PA, with maximal risk reduction at 402.6 and 428.1 minutes per week, respectively, beyond which no additional benefit was observed. An isotemporal substitution model showed that replacing light-intensity PA with moderate-intensity PA/vigorous-intensity PA reduced AAA risk, with greater benefit for vigorous-intensity PA.</p>
CONCLUSION: PA engagement is associated with a reduction in AAA burden, regardless of genetic risk. We identified distinct time thresholds for achieving maximum benefit among PA intensities, highlighting its potential role in exercise-based AAA prevention strategies.</p>
14 Keywords
- Accelerometry
- Aged
- Aortic Aneurysm, Abdominal
- Exercise
- Female
- Genetic Predisposition to Disease
- Humans
- Incidence
- Male
- Middle Aged
- Risk Assessment
- Risk Factors
- Surveys and Questionnaires
- United Kingdom
17 Authors
- Ru Li
- Fang Lei
- Bo Liu
- Lijin Lin
- Xuewei Huang
- Xingyuan Zhang
- Weifang Liu
- Tao Sun
- Yuanyuan Cao
- Qinghua Wu
- Li Zhang
- Fengjiao Hu
- Xiao-Jing Zhang
- Jingjing Cai
- Zhi-Gang She
- Yufeng Hu
- Hongliang Li
1 Application
| Application ID | Title |
|---|---|
| 77195 | Identifying the association factors and causal determinants in metabolic diseases |
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