| Title: | Circulating metabolites associated with psoriasis in the UK Biobank and the HUNT Study: A cross-sectional study of 470,352 participants |
| Journal: | British Journal of Dermatology |
| Published: | 30 Mar 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41911431/ |
| DOI: | https://doi.org/10.1093/bjd/ljag116 |
Publication 18151
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Abstract
BACKGROUND: Psoriasis is recognized as a systemic inflammatory disease associated with metabolic dysregulation. Understanding these metabolic changes may reveal biomarkers to elucidate disease mechanisms and predict comorbidities. While previous studies have identified psoriasis-associated metabolites, findings are often limited by sample sizes and lack validation.</p>
OBJECTIVES: To identify circulating metabolites associated with psoriasis, including disease severity and psoriatic arthritis. Further, we investigated whether the metabolic signature was disease-specific compared to other immune-mediated inflammatory diseases (IMIDs).</p>
METHODS: We performed a cross-sectional analysis of 470,352 White/European individuals from the UK Biobank (n=453,428) and HUNT (n=16,924). Nuclear Magnetic Resonance spectroscopy was used to quantify metabolite levels, covering lipoprotein fractions and subfractions, fatty acids, and small-molecular metabolites. For each metabolite, we performed multivariable linear regression adjusting for age, sex, BMI, smoking status, and use of lipid-lowering medications.</p>
RESULTS: The metabolomic profile of psoriasis was largely consistent across the two populations. In the model adjusted for age and sex, 123 metabolic measures were associated with psoriasis. After full adjustment, only Glycoprotein acetyls (GlycA) remained associated with psoriasis (coefficient [95% CI]: 0.09 [0.07-0.11] in UK Biobank and 0.11 [0.06-0.17] in HUNT). In HUNT, severe psoriasis exhibited more pronounced metabolic alterations compared to non-severe psoriasis. Across both populations, phenylalanine levels were highly elevated in psoriatic arthritis compared to cutaneous psoriasis (0.44 [0.29-0.60] in UK Biobank and 0.47 [0.28-0.67] in HUNT). In comparisons across IMIDs, atopic dermatitis and cutaneous-limited psoriasis exhibited milder metabolic alterations, and psoriasis in HUNT showed a distinct lipoprotein profile.</p>
CONCLUSIONS: This large-scale study confirms metabolic alterations in individuals with psoriasis and highlights phenylalanine as a potential biomarker for joint involvement in psoriasis. The distinct metabolomic profile of psoriasis relative to other IMIDs suggests a potentially unique systemic profile. These findings offer a foundation for advancing biomarker research and mechanistic studies for psoriasis.</p>
14 Authors
- Alya G A Arham
- Abhibhav Sharma
- Laurent F Thomas
- Ravi Ramessur
- Julia Debik
- Marion Denos
- Mari Hoff
- Vibeke Videm
- Lavinia Paternoster
- Catherine Smith
- Bjørn O Åsvold
- Guro F Giskeødegård
- Ben M Brumpton
- Mari Løset
1 Application
| Application ID | Title |
|---|---|
| 40135 | Gene and environment association studies in HUNT and UK Biobank |
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