| Title: | Five lipid-inflammation composite indices and obesity-related metabolic disorders, cardiovascular and renal diseases A multi-state trajectory analysis using data from the UK Biobank cohort |
| Journal: | Diabetes Research and Clinical Practice |
| Published: | 4 Apr 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41942013/ |
| DOI: | https://doi.org/10.1016/j.diabres.2026.113234 |
Publication 18098
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Abstract
BACKGROUND: Biomarkers that capture the dynamic transition from obesity to metabolic dysfunction and subsequent cardiorenal disease remain insufficient. This study evaluated stage-specific associations of lipid-inflammation indices across this continuum.</p>
METHODS: We included 109,442 obese adults (UK Biobank) across four stages, obesity (Stage 1), metabolic disorders (Stage 2), cardiorenal disease (Stage 3), and death (Stage 4). Five baseline indices (ApoB/A1-CRP, RCII, NHR, lymphocyte-to-HDL-C, monocyte-to-HDL-C) were evaluated. Markov multistate models were used to estimate transition-specific risks, with Cox regression and restricted cubic spline (RCS) analyses as complementary approaches.</p>
RESULTS: During a median follow-up of 15.73 years, 11.14% of participants progressed from Stage 1 to 2, and 25.88% from Stage 2 to 3. In fully adjusted model, ApoB/A1-CRP (HR, 1.07, 95% CI, 1.00-1.14, P = 0.048) and RCII (HR, 1.08, 95% CI, 1.01-1.15, P = 0.017) were significantly associated with Stage 2 to 3 progression. Upon Stage 3 stratification, NHR was primarily associated with mortality following cardiorenal disease onset. RCS analyses indicated significant non-linear associations for ApoB/A1-CRP, RCII, and NHR. RCII demonstrates robustness in sensitivity analysis.</p>
CONCLUSIONS: RCII is independently associated with the progression from metabolic disorders to cardiorenal diseases in obesity. It may serve as a clinically biomarker for early risk stratification.</p>
8 Authors
- Ran He
- Qikai Luo
- Taian Jin
- Qi Liu
- Yiwei Shang
- Zihan Fang
- Juan Jin
- Qiang He
1 Application
| Application ID | Title |
|---|---|
| 957249 | Associations of Genetic Variants, Environmental Exposures, and Clinical Risk Factors with Disease Progression and Health Outcomes in Patients with Chronic Non-Communicable Diseases |
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