| Title: | Genetic architecture and environmental risk factors of neurological and psychiatric disorders and their shared pathological mechanisms and pathways |
| Lead Institution: | Central South University |
| Principal investigator: |
Application 99093
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About
Most neurological and psychiatric disorders are complex diseases with various symptoms and these are caused by a range of genetic loci and environmental risk factors. Although a large number of studies have made a great effort for the pathogenesis from multiple dimensions, the exact pathogenic mechanisms of most neurological and psychiatric disorders still remain elusive. In addition, neurological disorders are often with psychiatric diseases, for example, depression and anxiety symptoms in stroke. Hence, there should be some share pathogenic mechanisms between neurological and psychiatric disorders. Given that some of the previous studies demonstrated inconsistent results partly due to relatively small sample size, it is urgent to investigate the pathogenesis of these disorders from multiple dimensions with large sample size based on biobanks. Based on high-quality data in UK Biobank, this project aims to comprehensively explore biomarkers for the occurrence and development of neurological and psychiatric disorders from multiple dimensions, and to explore novel shared mechanisms and pathways of these disorders. We anticipate identifying some novel risk or protective factors, which may shed light on the early prevention, diagnosis, and treatment of neurological and psychiatric disorders. In addition, by identifying risk and protective factors involved in neurological and psychiatric disorders, this project may facilitate the development of diseases prediction models for these disorders. We anticipate the project duration to be 36 months.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 19192 | The APOE ε4 allele affects the survival of patients with Parkinson's disease independent of dementia | Zheng Wang (+14) | 2025 | Journal of Translational Medicine |
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