| Title: | Selection of disease risk genes and construction of disease prediction model based on TWAS and sc-RNA data: Take colon cancer for example |
| Lead Institution: | China Pharmaceutical University |
| Principal investigator: |
Application 94184
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About
Aims: This study aims to find the causal gens which are hypothesized to be oncogenes with the help of Mendelian Randomization method. Scientific rationale: Mendelian Randomization is a form of statistical method that makes causal inference between exposure and outcome. In this study, the exposure is gene expression and the outcome is colon cancer. Project duration: Estimated duration of this project is expected to be 3 years. Public health impact: These putative causal oncogenes can be the priorities in the drug research and development, and provide new insights into the treatment of colon cancer.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 19276 | Shared Plasma Metabolites Mediate Causal Effects of Metabolic Diseases on Colorectal Cancer: A Two-Step Mendelian Randomization Study | Xinyi Shi (+6) | 2025 | Biomedicines |
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