About
The digestive tract is important in maintaining the function of the human body. Diseases of the organs in the digestive tract are harmful to our health. In recent years, different methods with promising therapeutic effects have been developed to treat digestive tract diseases. Despite advances in therapeutics, digestive tract diseases can lead to serious consequences and long-lasting burdens. Thus, "the best fight is the one you avoid", the prevention and prediction of digestive tract diseases are as important as treating them. Individual characteristics, such as lifestyles, psychological factors and genetic variations, could have far-reaching impacts on the development of digestive tract diseases. However, there are other factors that remain controversial, and indicators with high predictive sensitivity and accuracy remain deficient. It is important to provide such evidence based on large-scale studies.
In this 3-year project, we aim to 1) explore the risk factors that predispose people to the development of digestive tract disease. 2) identify indicators that can assist with the individualized prediction of digestive tract diseases. Our findings will help the public to take actions, for example, lifestyle modification, to prevent digestive tract diseases, and assist in the decision-making process of healthcare providers.
13 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|
| 11322 | Associations of habitual glucosamine use with SARS-CoV-2 infection and hospital admission and death with COVID-19: Evidence from a large population based cohort study | Meijun Meng (+13) | 2023 | Journal of Medical Virology |
| 12817 | Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population-based cohort study | Ruijie Zeng (+12) | 2024 | eLife |
| 15523 | Atmospheric Pollutants, Cardiometabolic Disorders, and Dementia in Trajectory Analysis: A 13-Year Longitudinal Cohort Study | Dong Chen (+16) | 2025 | Journal of the American Heart Association |
| 16444 | Causal association and genetic correlation of frailty with metabolic dysfunction-associated steatotic liver disease: Epidemiological and genetic analyses | Han Zhang (+14) | 2025 | The Innovation Medicine |
| 16886 | Early-life tobacco exposure, genetic susceptibility and incident colorectal cancer risk in UK biobank: A prospective cohort analysis | Yu Long (+13) | 2026 | Cancer Epidemiology |
| 18930 | Early-life tobacco exposure, genetic susceptibility, and multiple digestive diseases: evidence from two large cohorts and genetic analyses. | Qinming Li (+16) | 2025 | International Journal of Surgery |
| 11620 | Habitual fish oil use and risk of COVID-19-related outcomes: Evidence from a large scale cohort study and Mendelian randomization analysis | Yuying Ma (+12) | 2023 | Clinical Nutrition |
| 8716 | Long-term risks of respiratory diseases in patients infected with SARS-CoV-2: a longitudinal, population-based cohort study | Meijun Meng (+12) | 2024 | EClinicalMedicine |
| 14870 | Observational, causal relationship and shared genetic basis between cholelithiasis and gastroesophageal reflux disease: evidence from a cohort study and comprehensive genetic analysis | Yanlin Lyu (+10) | 2025 | GigaScience |
| 14762 | Physical Activity, Genetic Susceptibility, and Risk of Colorectal Cancer in Type 2 Diabetes: A Large Population-Based Cohort Study. | Yanjun Wu (+12) | 2025 | Deutsches Ärzteblatt international |
| 17190 | Plasma proteomic profiles identify biomarkers predicting Crohn's disease up to 16 years before onset | Jing Feng (+18) | 2025 | Nature Communications |
| 8963 | Risks of digestive diseases in long COVID: evidence from a population-based cohort study | Yuying Ma (+13) | 2024 | BMC Medicine |
| 11821 | The mediating effect of blood biomarkers in the associations between inflammatory bowel disease and incident psychiatric disorders: a prospective cohort study | Jing Feng (+13) | 2024 | International Journal of Surgery |
