| Title: | Impact of Modifiable and Intermediate Factors on Non-Communicable Diseases: A Comprehensive Analysis |
| Lead Institution: | LanZhou University |
| Principal investigator: |
Application 456996
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About
Non-communicable diseases (NCDs) account for over 70% of global deaths annually, including conditions such as cancer, cardiovascular diseases, chronic respiratory diseases, and diabetes. These diseases are largely driven by modifiable lifestyle factors, including poor diet, physical inactivity, obesity, smoking, and alcohol consumption. The increasing prevalence of NCDs underscores the urgent need for effective strategies in prevention and management. Recent research highlights not only the direct impact of lifestyle factors on NCDs but also the mediating mechanisms, such as blood pressure and metabolic markers, that may clarify these relationships. This project aims to explore the direct or indirect effects of modifiable factors-diet, BMI, waist circumference, smoking, alcohol consumption, and others-on NCDs such as cancer, Crohn's disease, and asthma. It will investigate how these factors influence NCDs through potential mediators like blood pressure and blood metabolites. The study will assess dietary patterns, BMI categories, abdominal obesity, smoking behavior, alcohol intake, and others in relation to the risk of various NCDs. Additionally, it will examine how lifestyle factors affect blood pressure and the role of blood metabolites, and others, in mediating the relationship between these factors and NCDs. Using logistic regression and/or Cox proportional hazards models, the research will analyze data collected over 36 months. The outcomes will include identifying associations between modifiable factors and NCDs, uncovering mediators that explain how these factors impact disease risk, and providing valuable insights for the prevention, treatment, and prognosis of NCDs. Ultimately, this research aims to enhance our understanding of how lifestyle modifications can reduce the risk of NCDs.4 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 18418 | Cheese consumption and lower cholelithiasis risk a prospective UK biobank study with HDL-C mediation | Wenwen Yang (+4) | 2026 | npj Science of Food |
| 18306 | Circulating IGF-1 levels and 27 digestive diseases: 461,401 UK biobank prospective analysis | Wenwen Yang (+5) | 2026 | Growth Hormone & IGF Research |
| 18359 | IGF-1 as a mediator in the association between body mass index and risk of liver cancer: A prospective analysis of 432,203 participants from the UK biobank | Wenwen Yang (+4) | 2026 | Growth Hormone & IGF Research |
| 18241 | The Mediating Role of Serum Phosphate in the BMI-Breast Cancer Association: A Prospective Study from the UK Biobank | Wenwen Yang (+3) | 2026 | Clinical Breast Cancer |
Enabling scientific discoveries that improve human health