| Title: | The interplay between genetic and environmental risk factors of schizophrenia and bipolar disorder in influencing the mental health status in the general population |
| Lead Institution: | Karolinska Institutet |
| Principal investigator: |
Application 448056
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About
There have been many studies investigating gene-environment interaction in the development of schizophrenia(SCZ) and bipolar disorder(BIP), with some indications that genetic risk can be amplified or diminished in different environmental contexts. Moreover, an abundance of research indicates that these genetic and environmental factors can also independently predict mental health status in the general population. However, the mechanisms by which they interact to influence the mental health among the general population remain largely unknown. Therefore, the current study aims to test the (1) independent, (2) combined, and (3) interaction effects of polygenic risk scores and environmental risk factors of schizophrenia and bipolar disorder on a series of mental health outcomes among the general population. Environmental risk factors will include adverse childhood experiences, migration, urbanicity, infection and substance use/abuse. The mental health outcomes will include self-report mental health measures, psychotic experiences, help-seeking for mental health issues, cumulative psychiatric/somatic disease burden, and suicide or self-harm attempts. Findings from this study will deepen our understanding of the mechanisms underlying general psychopathology and facilitate the early detection and management of mental health issues in the general population. For the outcomes of self-reported mental health measures, psychotic experiences, help-seeking for mental health issues, and suicide or self-harm attempts, binary logistic regression models will be fitted. For outcomes of cumulative psychiatric/somatic disease burden, Poisson regression models with a log-time offset term will be fitted.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 18084 | Joint effects of childhood adversity and genetic risk for psychosis on psychopathology in the UK Biobank | Zheng-An Lu (+2) | 2026 | Psychological Medicine |
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