| Title: | Examine the Genetic and Environmental Contributions to Women's Health and Female Reproductive System Diseases by Integrating Population-Based Studies and Multi-Omics Analyses |
| Lead Institution: | Fujian Medical University |
| Principal investigator: |
Application 312092
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About
Aim(s): In this project, we aim to combine studies of large groups of people with advanced genetic analyses to better understand how genes and the environment affect the development of diseases in the female reproductive system.. Scientific rationale: Women of all ages and backgrounds have both similarities and differences in their bodies at different life stages. By studying these traits using data from the UK Biobank, we can find personalized treatments for female health issues that may be different from those used for men or specific to certain ages and ethnicities. However, we still have much to learn about the specific factors that cause diseases in women. The continuous updating of a large amount of multi-omics data from UKB allows us to explore these unanswered questions. Project duration: 36 months. Public health impact: We believe that our plan is important because it will help us understand what causes diseases in the female reproductive system at different ages and in different ethnic groups. This understanding will help doctors design better treatments tailored to each person's needs, which will ultimately help patients with these diseases.2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 18746 | Myokine Cathepsin B as a Key Muscle-Brain Axis Regulator Mediates Treadmill-Running-Induced Hippocampal Neurogenesis and Cognitive Improvement in Mice | Xuchang Zhou (+16) | 2026 | Research |
| 18523 | Polygenic risk score-guided personalized osteoporosis screening: a population-based study | Dongxue Wang (+6) | 2026 | BMC Medicine |
Enabling scientific discoveries that improve human health