| Title: | Unveiling the Interplay of comorbidities Patterns in Chronic Diseases: Exploring Trends, Risk Factors, Pathogenesis, Prognosis, and Precision Therapeutics |
| Lead Institution: | Nanjing Drum Tower Hospital |
| Principal investigator: |
Application 177180
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About
Our research project aims to understand why people often experience multiple chronic diseases at the same time and how we can better the prevention, diagnosis, and treatment of these complex health challenges. With the aging population and changes in lifestyle, it has become common for individuals to face more than one chronic condition simultaneously, affecting their overall well-being and posing higher health risks. Aims: We want to uncover the patterns of multiple chronic diseases within the UK Biobank data, a vast collection of information about people's genes, environment, behaviors, lab results, images, multi-omics data and health-related outcomes. By studying this data, we hope to identify common trends, understand the factors that contribute to comorbidities in chronic diseases , and explore ways to provide more personalized and effective treatments. Scientific Rationale: While we know that having multiple chronic conditions can impact both physical and mental health and increase the risk of serious outcomes, there is still much we don't understand. Our project aims to fill this knowledge gap by examining a wide range of data from the UK Biobank. We believe that by looking at the bigger picture - combining genetic, environmental, and lifestyle information - we can gain insights that will help us manage and treat these conditions more effectively. Project Duration: This research will take 36 months and we will meticulously analyze the data, draw connections between different factors, and derive meaningful conclusions. This duration allows us to conduct a thorough investigation, ensuring the reliability and accuracy of our findings. Public Health Impact: The impact of this research extends to public health in several ways. By understanding the trends and complexities of multiple chronic diseases, we can inform healthcare policies and practices, enabling better prevention strategies. Early diagnosis and personalized treatments can be developed, enhancing the quality of life for individuals facing these health challenges. What sets our research apart is the incorporation of our center's data and the infusion of traditional Chinese medicine interventions into precision treatments. This unique blend not only embraces the cutting-edge aspects of Western medicine but also integrates the holistic principles of traditional Chinese medicine, offering a comprehensive approach to health. Ultimately, our goal is to contribute to a healthier society by reducing the burden of chronic diseases, improving patient outcomes, and guiding healthcare decisions based on a more comprehensive understanding of these complex health issues.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 18184 | Dementia Burden and Modifiable Risk Factors in Type 2 Diabetes: Population Based, Prospective Cohort Study | Chuanrui Sun (+6) | 2026 | Diabetes Obesity and Metabolism |
Enabling scientific discoveries that improve human health