| Title: | Identifying epidemiological and genetic risk factors for benign prostatic hyperplasia using the UK Biobank |
| Lead Institution: | Central South University |
| Principal investigator: |
Application 135237
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About
The degree of population aging is progressively deepening across nations, rendering population aging a global phenomenon. Benign prostatic hyperplasia (BPH) is a common ailment among elderly males. The national disease burden attributed to BPH is anticipated to continue its ascent. The UK Biobank, encompassing a vast multidimensional database housing genetic and non-genetic health information, proves exceptionally instrumental in identifying risk factors pertinent to BPH. We aim to meticulously investigate BPH associated risk factors through the utilization of the UK Biobank. Objectives :1.Identifying potential risk factors for BPH;2.Elucidating the molecular epidemiology of BPH;3.Developing and validating risk prediction and prognosis models;4.Calculating multi-gene risk scores. Through a comprehensive exploration of plausible risk factors, this endeavor not only advances our understanding of BPH development and prognosis but also contributes to the enhanced management of BPH. Project Duration: This project is estimated to take approximately 36 months to complete.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 18295 | Plasma metabolomics identifies key metabolites and improves the prediction of benign prostatic hyperplasia. | Xinkai Pan (+8) | 2026 | International Journal of Surgery |
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