| Title: | Plasma Multiomics Links Early-Life Adversity to Disease and Cardiometabolic Health: A Population-Based Cohort Study |
| Journal: | Journal of the American Heart Association |
| Published: | 28 Apr 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42047201/ |
| DOI: | https://doi.org/10.1161/jaha.125.047882 |
Publication 20655
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Abstract
BACKGROUND: Childhood adversity (CA) is associated with increased cardiovascular and cardiometabolic risk, but the molecular mechanisms remain unclear. We aimed to identify CA-related metabolomic and proteomic signatures and evaluate their roles in linking CA to incident diseases.</p>
METHODS: This prospective cohort study included 153 225 participants aged 48 to 64 years. CA was assessed using the Childhood Trauma Screener-5, capturing cumulative (0-5 domains) and individual adversity exposures. Plasma metabolomics and proteomics data were integrated to derive CA-related molecular signatures. Cox proportional hazards model was used to evaluate associations between CA, molecular signatures, and 58 incident diseases and mortality. Mediation analyses quantified the role of multiomics signatures.</p>
RESULTS: Each additional CA domain was associated with higher risk of 49 of 58 incident diseases (hazard ratios [HRs], 1.024-1.338) and a 7.3% higher all-cause mortality risk. Focusing on cardiometabolic health, the CA-related metabolic and proteomic signatures were independently associated with incident disease. Per 1-SD increase in the cumulative CA metabolic signature, the highest observed HR was 1.313 (95% CI, 1.278-1.349) for incident diabetes, and the risk for hypertension was also increased (HR, 1.136 95% CI, 1.114-1.159). Similarly, the proteomic signature was strongly associated with incident diabetes (HR, 1.645 95% CI, 1.489-1.818) and hypertension (HR, 1.223 95% CI, 1.155-1.295). The cumulative CA metabolic and proteomic signatures mediated up to 25.5% and 46.8% of the association with hypertension, respectively.</p>
CONCLUSIONS: CA is associated with a broad spectrum of diseases and mortality, with particularly strong links to cardiometabolic health. Multiomics signatures partially mediated these associations.</p>
15 Keywords
- Adverse Childhood Experiences
- Biomarkers
- Cardiometabolic Risk Factors
- Cardiovascular Diseases
- Female
- Humans
- Incidence
- Male
- Metabolomics
- Middle Aged
- Multiomics
- Prospective Studies
- Proteomics
- Risk Assessment
- Risk Factors
11 Authors
- Qida He
- Mengtong Sun
- Feng Huang
- Xianzhu Cong
- Xun Sun
- Yue Huang
- Aimin Wang
- Yujia Kong
- Fuyan Shi
- Suzhen Wang
- Na Sun
1 Application
| Application ID | Title |
|---|---|
| 78500 | Exploring the specific risk factors and key biomarkers for stroke using biochemical indicators, lifestyle, environmental factors and genetic information |
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